Chen Fei, Chen Ken
Department of Geriatric, Chongqing Mental Health Center, 401147 Chongqing, China.
Alpha Psychiatry. 2025 Aug 25;26(4):46031. doi: 10.31083/AP46031. eCollection 2025 Aug.
The negative impact of obesity on cognitive function (CF) is well-established; nevertheless, no prior studies have explored the link between conicity index and cognitive performance. This research sought to investigate the link between conicity index and cognitive impairment.
Data were obtained from a cross-sectional analysis of the National Health and Nutrition Examination Survey 2011-2014 (NHANES), with CF evaluated by the total scores of three cognitive tests (TCT), the delayed recall test (DRT), the immediate recall test (IRT), the animal fluency test (AFT), and the digit symbol substitution test (DSST). The conicity index was derived from waist circumference, height, and weight. Multiple linear regression, smooth curve fitting, and subgroup interaction analyses were utilized to explore the correlation between conicity index and cognitive performance.
The study included 2752 subjects and the results indicated that increasing conicity index was markedly associated with declining CF. In fully adjusted models, the conicity index was linked to reductions in total cognitive score (β = -16.35, 95% confidence interval (CI): -26.68 to -6.02, = 0.0019) and DRT (β = -1.52, 95% CI: -2.74 to -0.30, = 0.0151), IRT (β = -2.93, 95% CI: -5.37 to -0.48, = 0.0190), AFT (β = -2.03, 95% CI: -4.88 to 0.82, = 0.1636), and DSST (β = -9.88, 95% CI: -17.11 to -2.65, = 0.0075) scores. However, the negative association between conicity index and AFT score was not statistically significant.
Lower CF is associated with a higher conicity index. The conicity index is useful for the early detection of cognitive decline.
肥胖对认知功能（CF）的负面影响已得到充分证实；然而，此前尚无研究探讨锥度指数与认知表现之间的联系。本研究旨在调查锥度指数与认知障碍之间的联系。
数据来自2011 - 2014年美国国家健康与营养检查调查（NHANES）的横断面分析，通过三项认知测试（TCT）、延迟回忆测试（DRT）、即时回忆测试（IRT）、动物流畅性测试（AFT）和数字符号替换测试（DSST）的总分评估认知功能。锥度指数由腰围、身高和体重得出。采用多元线性回归、平滑曲线拟合和亚组交互分析来探讨锥度指数与认知表现之间的相关性。
该研究纳入了2752名受试者，结果表明锥度指数升高与认知功能下降显著相关。在完全调整模型中，锥度指数与总认知得分降低（β = -16.35，95%置信区间（CI）：-26.68至-6.02，P = 0.0019）、DRT得分降低（β = -1.52，95% CI：-2.74至-0.30，P = 0.0151）、IRT得分降低（β = -2.93，95% CI：-5.37至-0.48，P = 0.0190）以及DSST得分降低（β = -9.88，95% CI：-17.11至-2.65，P = 0.0075）相关。然而，锥度指数与AFT得分之间的负相关无统计学意义。
较低的认知功能与较高的锥度指数相关。锥度指数有助于早期发现认知衰退。
