Int J Oral Maxillofac Implants. 2021 Jul-Aug;36(4):703-714. doi: 10.11607/jomi.8695.
To evaluate the impact on healing of bioactivation with argon plasma of a xenogeneic graft with adequate fixation but poor adaptation to the native host bone.
Xenogeneic grafts were either treated with argon plasma or left untreated and randomly secured with a titanium screw to both lateral aspects of the mandible angle of rabbits. A discrepancy was obtained between the xenograft and the mandible due to the convexity of the recipient site. Collagen membranes were placed on the grafts. Thirty animals were included and euthanized in groups of 10 after 2, 6, and 10 weeks, respectively. Histomorphometric evaluations were performed on ground sections. Newly formed bone was the primary outcome, while the distance between the peak of new bone inside the graft and the upper surface of the graft, the xenograft percentages, and the area of the xenograft were considered as secondary variables. The Wilcoxon test was applied for statistical analyses.
After 2 weeks of healing, gaps of ~0.5 mm were observed at the interface between the graft and the recipient sites, and new bone was mainly located in the interface and within the inferior regions of the grafts. New bone increased over time in all regions, including those in the upper zones of the graft, reaching proportions of 20.3% ± 6.5% and 19.3% ± 7.4% (P = .484) after 10 weeks in the plasma and control groups, respectively. The mean distance between the peak of new bone inside the graft and the upper surface of the graft decreased between 2 and 10 weeks of healing from 1.4 mm to 0.4 mm and from 1.7 mm to 0.3 mm at the plasma and control sites, respectively.
The xenogeneic grafts of both groups were incorporated into the recipient sites by newly formed bone that presented a growth close to the upper surface of the graft. The bioactivation with argon plasma did not improve healing.
评估对具有适当固定但与宿主骨适应性差的异种移植物进行氩等离子体生物活化对愈合的影响。
将异种移植物用氩等离子体处理或不处理，然后用钛螺钉随机固定在兔下颌角的两侧。由于受区的凸度，异种移植物与下颌骨之间存在差异。将胶原膜放置在移植物上。将 30 只动物分为 3 组，每组 10 只，分别在 2、6 和 10 周时处死。对磨片进行组织形态计量学评估。新形成的骨是主要的结果，而移植物内新骨峰值与移植物上表面之间的距离、异种移植物的百分比和异种移植物的面积被认为是次要变量。应用 Wilcoxon 检验进行统计学分析。
在愈合的 2 周时，在移植物和受区之间的界面处观察到约 0.5mm 的间隙，新骨主要位于界面和移植物的下侧区域。所有区域的新骨随时间增加，包括移植物的上侧区域，在等离子体组和对照组中，分别在第 10 周时达到 20.3%±6.5%和 19.3%±7.4%（P=0.484）。在愈合的 2 至 10 周期间，移植物内新骨峰值与移植物上表面之间的平均距离从 1.4mm 减少到 0.4mm，从 1.7mm 减少到 0.3mm，在等离子体组和对照组中分别。
两组的异种移植物均通过接近移植物上表面生长的新骨与受区结合。氩等离子体的生物活化并没有改善愈合。
