Natural and Medical Sciences Research Center, University of Nizwa, P.O. Box 33, Postal Code 616, Birkat Al Mauz, Nizwa, Oman.
Natural and Medical Sciences Research Center, University of Nizwa, P.O. Box 33, Postal Code 616, Birkat Al Mauz, Nizwa, Oman.
Phytochemistry. 2021 Nov;191:112897. doi: 10.1016/j.phytochem.2021.112897. Epub 2021 Aug 17.
Frankincense of Boswellia species has long been used in traditional medicines, mainly for its interesting anti-inflammatory and anti-depressant properties of its di- and triterpenes. Boswellic acids (triterpenes) and cembranoids (diterpenes) are the major constituents of frankincense from all reported species which are responsible for the overall biological activity of frankincense. Boswellic acids have been thoroughly investigated for decades but cembranoids have attracted considerable attention only recently, and a good number of publications have highlighted the important role of these 14-membered rings in contributing to the superior anti-inflammatory activity of the sacred resin. Partial and total syntheses of some cembranoids from frankincense have been reported. Their therapeutic potential is not limited to the well proven anti-inflammatory activity but also to their recently reported anti-depressant properties. There is a considerable number of publications in the field of cembranoids of Boswellia species where we feel a review in this topic will be of interest to the readership of Phytochemistry. In this article we have discussed the chemistry (isolation and chemical structures as well as synthetic studies), biogenesis and bioactivity of the reported cembranoids of Boswellia species. The structural discrepancies due to wrongly assigned structures of some cembranoids have been highlighted and corrected. We have covered the related literature up to the end of 2020.
乳香树属植物的乳香自古以来就在传统药物中被广泛使用，主要是因为其所含的二萜和三萜具有有趣的抗炎和抗抑郁特性。乳香酸（三萜）和角鲨烯（二萜）是所有报道的乳香物种的主要成分，它们负责乳香的整体生物活性。乳香酸已经被彻底研究了几十年，但角鲨烯最近才引起了相当大的关注，并且大量出版物强调了这些 14 元环在赋予神圣树脂卓越抗炎活性方面的重要作用。已经报道了一些乳香中二萜的部分和全合成。它们的治疗潜力不仅限于已被证实的抗炎活性，还包括它们最近报道的抗抑郁特性。在乳香树属植物的角鲨烯领域有相当数量的出版物，我们认为在这个主题上的综述将引起植物化学领域读者的兴趣。在本文中，我们讨论了乳香树属植物中报道的角鲨烯的化学（分离和化学结构以及合成研究）、生物发生和生物活性。由于一些角鲨烯的结构被错误分配，我们强调并纠正了结构差异。我们涵盖了截至 2020 年底的相关文献。
