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博斯韦尔醇A - I，源自[植物名称]油胶树脂的结构多样的二萜类化合物及其对转化生长因子的抑制活性。 （注：原文中“from the Oleo-Gum Resin of ”这里“of”后面缺少具体植物名称）

Boswellianols A-I, Structurally Diverse Diterpenoids from the Oleo-Gum Resin of and Their TGF- Inhibition Activity.

作者信息

Lin Zhi-Rong, Bao Meng-Yu, Xiong Hao-Ming, Cao Dai, Bai Li-Ping, Zhang Wei, Chen Cheng-Yu, Jiang Zhi-Hong, Zhu Guo-Yuan

机构信息

State Key Laboratory of Quality Research in Chinese Medicines, Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Disease, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau 999078, China.

Jiaheng Pharmaceutical Technology Co., Ltd., Zhuhai 519000, China.

出版信息

Plants (Basel). 2024 Apr 11;13(8):1074. doi: 10.3390/plants13081074.

DOI:10.3390/plants13081074
PMID:38674483
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11054202/
Abstract

Olibanum, a golden oleo-gum resin from species in the genus ( family), is a famous traditional herbal medicine widely used around the world. Previous phytochemical studies mainly focused on the non-polar fractions of olibanum. In this study, nine novel diterpenoids, boswellianols A-I (-), and three known compounds were isolated from the polar methanolic fraction of the oleo-gum resin of . Their structures were determined through comprehensive spectroscopic analysis as well as experimental and calculated electronic circular dichroism (ECD) data comparison. Compound is a novel diterpenoid possessing an undescribed prenylmaaliane-type skeleton with a 6/6/3 tricyclic system. Compounds - were unusual prenylaromadendrane-type diterpenoids, and compounds - were new highly oxidized cembrane-type diterpenoids. Compounds and showed significant transforming growth factor (TGF-) inhibitory activity via inhibiting the TGF--induced phosphorylation of Smad3 and the expression of fibronectin and N-cadherin (the biomarker of the epithelial-mesenchymal transition) in a dose-dependent manner in LX-2 human hepatic stellate cells, indicating that compounds and should be potential anti-fibrosis agents. These findings give a new insight into the chemical constituents of the polar fraction of olibanum and their inhibitory activities on the TGF-/Smad signaling pathway.

摘要

乳香是一种来自乳香属（橄榄科）植物的金色油胶树脂，是一种在世界各地广泛使用的著名传统草药。以往的植物化学研究主要集中在乳香的非极性部分。在本研究中，从乳香油胶树脂的极性甲醇部分分离出9种新型二萜类化合物，乳香醇A - I（-），以及3种已知化合物。通过综合光谱分析以及实验和计算的电子圆二色性（ECD）数据比较确定了它们的结构。化合物是一种新型二萜类化合物，具有未描述的异戊烯基马莲烷型骨架，带有6/6/3三环体系。化合物 - 是不寻常的异戊烯基芳樟烷型二萜类化合物，化合物 - 是新的高度氧化的西松烷型二萜类化合物。化合物和在LX - 2人肝星状细胞中通过剂量依赖性抑制TGF - 诱导的Smad3磷酸化以及纤连蛋白和N - 钙黏蛋白（上皮 - 间质转化的生物标志物）的表达，显示出显著的转化生长因子（TGF - ）抑制活性，表明化合物和应该是潜在的抗纤维化剂。这些发现为乳香极性部分的化学成分及其对TGF - /Smad信号通路的抑制活性提供了新的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45a9/11054202/1f5670dd6435/plants-13-01074-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45a9/11054202/8e86ab870202/plants-13-01074-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45a9/11054202/6c8cfe677339/plants-13-01074-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45a9/11054202/b2607017d48a/plants-13-01074-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45a9/11054202/7682c04e4d69/plants-13-01074-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45a9/11054202/c744955282bf/plants-13-01074-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45a9/11054202/cbd7938a5a38/plants-13-01074-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45a9/11054202/1f5670dd6435/plants-13-01074-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45a9/11054202/8e86ab870202/plants-13-01074-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45a9/11054202/6c8cfe677339/plants-13-01074-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45a9/11054202/b2607017d48a/plants-13-01074-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45a9/11054202/7682c04e4d69/plants-13-01074-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45a9/11054202/c744955282bf/plants-13-01074-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45a9/11054202/cbd7938a5a38/plants-13-01074-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45a9/11054202/1f5670dd6435/plants-13-01074-g007.jpg

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