Department of Obstetrics and Gynecology, National Cerebral and Cardiovascular Center, Suita, Japan.
Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.
J Obstet Gynaecol Res. 2021 Nov;47(11):4049-4054. doi: 10.1111/jog.14961. Epub 2021 Aug 19.
Chronic active Epstein-Barr virus (CAEBV) infection characterized by persistent infectious mononucleosis-like symptoms can lead to cardiovascular diseases. We encountered two pregnant women with CAEBV histories complicated with cardiovascular diseases. A 36-year-old woman with a history of myocardial infarction due to CAEBV and coronary artery bypass grafting became pregnant. Her left ventricular ejection fraction (LVEF) decreased, and cesarean section was performed at 36 weeks of gestation. Her LVEF recovered after delivery. A 32-year-old woman with a history of CAEBV and chronic hypertension was diagnosed with mild pulmonary arterial hypertension (PAH) after conception. She strongly desired to continue the pregnancy. She became complicated with severe superimposed preeclampsia at 31 weeks of gestation, and cesarean section was performed. Her PAH did not deteriorate during pregnancy or the postpartum period. Women treated for CAEBV, even with complete remission, require a preconception evaluation focused on the cardiovascular system and careful management of their pregnancy.
慢性活动性 EBV（CAEBV）感染的特征为持续性传染性单核细胞增多症样症状，可导致心血管疾病。我们遇到了两名有 CAEBV 病史并伴有心血管疾病的孕妇。一名 36 岁的妇女因 CAEBV 和冠状动脉旁路移植术导致心肌梗死，再次怀孕。她的左心室射血分数（LVEF）降低，在妊娠 36 周时行剖宫产术。分娩后她的 LVEF 恢复正常。另一名 32 岁的妇女有 CAEBV 和慢性高血压病史，在怀孕后被诊断为轻度肺动脉高压（PAH）。她强烈希望继续妊娠。她在妊娠 31 周时并发严重的重叠子痫前期，行剖宫产术。她在妊娠和产后期间的 PAH 并未恶化。接受 CAEBV 治疗的女性，即使完全缓解，也需要进行针对心血管系统的孕前评估，并对其妊娠进行仔细管理。
