Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea.
Neuroscience Center, Samsung Medical Center, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea.
Sci Rep. 2021 Aug 19;11(1):16926. doi: 10.1038/s41598-021-96443-z.
Fatigue is a common and disabling non-motor symptom (NMS) of Parkinson's disease (PD); however, it has been poorly understood in patients with progressive supranuclear palsy (PSP). We investigated the association between fatigue, clinical features, and other NMS in patients with probable PSP. In 72 probable PSP patients, fatigue was investigated using the Parkinson Fatigue Scale (PFS). Further, all patients were evaluated using the PSP rating scale (PSPRS), Beck Depression Inventory (BDI), Mini-Mental State Examination (MMSE), Frontal Assessment Battery (FAB), PD Sleep Scale (PDSS), NMS scale (NMSS), PD Questionnaire-39 summary index (PDQ-39 SI), and Scale for outcomes in PD-Autonomic (SCOPA-AUT). The prevalence of fatigue assessed by PFS was 38.9% (28/72) in patients with PSP. The secondary fatigue was defined as fatigued patients with depression and/or sleep disturbances. We divided the patients into primary (n = 15), secondary (n = 13), and non-fatigue groups. There were no differences in age, sex, disease duration, and PSPRS, PDSS, MMSE, and FAB scores among the three groups. The primary fatigue group had higher scores in PDQ-39 SI compared to the non-fatigue group. The secondary fatigue group showed higher scores in NMSS, PDQ-39 SI, and SCOPA-AUT compared to the non-fatigue group. PFS was positively correlated with NMSS and PDQ-39 SI and SCOPA-AUT. Fatigue is common in patients with PSP and is associated with the NMS and the quality of life in these patients. The present study provides meaningful insight into fatigue in patients with PSP.
疲劳是帕金森病（PD）常见且致残的非运动症状（NMS）；然而，在进行性核上性麻痹（PSP）患者中，其了解甚少。我们研究了疲劳与可能的 PSP 患者的临床特征和其他 NMS 之间的关系。在 72 名可能的 PSP 患者中，使用帕金森疲劳量表（PFS）调查疲劳。此外，所有患者均使用 PSP 评定量表（PSPRS）、贝克抑郁量表（BDI）、简易精神状态检查（MMSE）、额叶评定量表（FAB）、PD 睡眠量表（PDSS）、NMS 量表（NMSS）、PD 问卷-39 综合指数（PDQ-39 SI）和 PD 自主神经量表（SCOPA-AUT）进行评估。使用 PFS 评估 PSP 患者的疲劳患病率为 38.9%（28/72）。二级疲劳定义为伴有抑郁和/或睡眠障碍的疲劳患者。我们将患者分为原发性（n=15）、继发性（n=13）和非疲劳组。三组患者的年龄、性别、病程、PSPRS、PDSS、MMSE 和 FAB 评分均无差异。与非疲劳组相比，原发性疲劳组的 PDQ-39 SI 评分较高。与非疲劳组相比，继发性疲劳组的 NMSS、PDQ-39 SI 和 SCOPA-AUT 评分较高。PFS 与 NMSS 和 PDQ-39 SI 和 SCOPA-AUT 呈正相关。疲劳在 PSP 患者中很常见，与这些患者的 NMS 和生活质量有关。本研究为 PSP 患者的疲劳提供了有意义的见解。
