• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

不同药物洗脱聚合物膜涂层的模拟电极阵列植入豚鼠耳蜗的听力保护效果。

Hearing Protection Outcomes of Analog Electrode Arrays Coated with Different Drug-Eluting Polymer Films Implanted into Guinea Pig Cochleae.

机构信息

Department of Otorhinolaryngology Head and Neck Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, People's Republic of China.

Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases (14DZ2260300), Shanghai, 200125, People's Republic of China.

出版信息

Drug Des Devel Ther. 2021 Aug 11;15:3443-3450. doi: 10.2147/DDDT.S318117. eCollection 2021.

DOI:10.2147/DDDT.S318117
PMID:34413631
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8370035/
Abstract

OBJECTIVE

To investigate the hearing protection outcomes of different drug-eluting analog electrode arrays implanted into guinea pig cochleae.

METHODS

Sixty guinea pigs were randomly divided into a negative control group and five experimental groups implanted separately with blank (drug carrier), dexamethasone (DXM), aracytine (Ara-C), Ara-C+DXM, and nicotinamide adenine dinucleotide (NAD+) eluting analog electrode arrays. Micro CT was used to supervise the surgical procedure. Auditory brainstem response (ABR) thresholds of the guinea pigs were measured and analyzed.

RESULTS AND CONCLUSIONS

Compared with the negative control, all other groups showed a significant increase in ABR threshold (p<0.001) after surgery. Among them, there was no obvious difference between the blank (0 vs 90 days: 59.70±10.57 vs 64.60±9.47 dB SPL) and the NAD+ group (0 vs 90 days: 59.90±9.87 vs 64.70±8.65 dB SPL). On the other hand, the ABR thresholds in the DXM (0 days: 58.10±10.73 dB SPL; 90 days: 51.70±9.07 dB SPL) and the Ara-C group (0 days: 59.00±10.05 dB SPL; 90 days: 51.60±8.48 dB SPL) decreased significantly compared with the former two groups (p<0.001). However, the Ara-C+DXM group showed no further benefit (p>0.05). In addition, a significantly higher survival rate of spiral ganglion neurons in cochleae was observed in the Ara-C and/or DXM groups.

摘要

目的

研究不同载药模拟电极阵列植入豚鼠耳蜗后的听力保护效果。

方法

60 只豚鼠随机分为阴性对照组和 5 个实验组，分别植入空白（药物载体）、地塞米松（DXM）、阿糖胞苷（Ara-C）、Ara-C+DXM 和烟酰胺腺嘌呤二核苷酸（NAD+）洗脱模拟电极阵列。微 CT 用于监测手术过程。测量并分析豚鼠的听觉脑干反应（ABR）阈值。

结果与结论

与阴性对照组相比，术后所有组的 ABR 阈值均显著升高（p<0.001）。其中，空白组（0 天 vs 90 天：59.70±10.57 vs 64.60±9.47 dB SPL）和 NAD+组（0 天 vs 90 天：59.90±9.87 vs 64.70±8.65 dB SPL）之间差异无统计学意义。另一方面，DXM 组（0 天：58.10±10.73 dB SPL；90 天：51.70±9.07 dB SPL）和 Ara-C 组（0 天：59.00±10.05 dB SPL；90 天：51.60±8.48 dB SPL）的 ABR 阈值与前两组相比明显下降（p<0.001）。然而，Ara-C+DXM 组并未显示出进一步的益处（p>0.05）。此外，在 Ara-C 和/或 DXM 组中观察到耳蜗螺旋神经节神经元的存活率显著提高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9ff/8370035/6f5dc19deb81/DDDT-15-3443-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9ff/8370035/ba53e1383b0e/DDDT-15-3443-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9ff/8370035/120dcf68539a/DDDT-15-3443-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9ff/8370035/10c3082c70bd/DDDT-15-3443-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9ff/8370035/edd9424daafd/DDDT-15-3443-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9ff/8370035/44bd51d5a82f/DDDT-15-3443-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9ff/8370035/6f5dc19deb81/DDDT-15-3443-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9ff/8370035/ba53e1383b0e/DDDT-15-3443-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9ff/8370035/120dcf68539a/DDDT-15-3443-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9ff/8370035/10c3082c70bd/DDDT-15-3443-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9ff/8370035/edd9424daafd/DDDT-15-3443-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9ff/8370035/44bd51d5a82f/DDDT-15-3443-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9ff/8370035/6f5dc19deb81/DDDT-15-3443-g0006.jpg

相似文献

1
Hearing Protection Outcomes of Analog Electrode Arrays Coated with Different Drug-Eluting Polymer Films Implanted into Guinea Pig Cochleae.不同药物洗脱聚合物膜涂层的模拟电极阵列植入豚鼠耳蜗的听力保护效果。
Drug Des Devel Ther. 2021 Aug 11;15:3443-3450. doi: 10.2147/DDDT.S318117. eCollection 2021.
2
Development of a safe dexamethasone-eluting electrode array for cochlear implantation.用于人工耳蜗植入的安全地塞米松洗脱电极阵列的研发。
Cochlear Implants Int. 2014 Sep;15(5):254-63. doi: 10.1179/1754762813Y.0000000054. Epub 2014 Jan 3.
3
Local dexamethasone therapy conserves hearing in an animal model of electrode insertion trauma-induced hearing loss.局部地塞米松治疗可在电极插入创伤性听力损失动物模型中保留听力。
Otol Neurotol. 2007 Sep;28(6):842-9. doi: 10.1097/mao.0b013e31805778fc.
4
Long-term effects and potential limits of intratympanic dexamethasone-loaded hydrogels combined with dexamethasone-eluting cochlear electrodes in a low-insertion trauma Guinea pig model.鼓室内载地塞米松水凝胶联合地塞米松洗脱耳蜗电极植入低创性豚鼠模型的长期效果和潜在局限性。
Hear Res. 2019 Dec;384:107825. doi: 10.1016/j.heares.2019.107825. Epub 2019 Oct 17.
5
Effects of a dexamethasone-releasing implant on cochleae: A functional, morphological and pharmacokinetic study.地塞米松缓释植入物对耳蜗的影响：一项功能、形态学和药代动力学研究。
Hear Res. 2015 Sep;327:89-101. doi: 10.1016/j.heares.2015.04.019. Epub 2015 May 15.
6
Cochlear implant and inflammation reaction: Safety study of a new steroid-eluting electrode.人工耳蜗与炎症反应：新型类固醇洗脱电极的安全性研究
Hear Res. 2016 Jun;336:44-52. doi: 10.1016/j.heares.2016.04.005. Epub 2016 Apr 21.
7
Effects of Implantation and Reimplantation of Cochlear Implant Electrodes in an In Vivo Animal Experimental Model (Macaca fascicularis).在体内动物实验模型（食蟹猴）中人工耳蜗电极植入及再植入的效果
Ear Hear. 2017 Jan/Feb;38(1):e57-e68. doi: 10.1097/AUD.0000000000000350.
8
Impedance Changes and Fibrous Tissue Growth after Cochlear Implantation Are Correlated and Can Be Reduced Using a Dexamethasone Eluting Electrode.人工耳蜗植入后的阻抗变化与纤维组织生长相关，使用地塞米松洗脱电极可降低这种相关性。
PLoS One. 2016 Feb 3;11(2):e0147552. doi: 10.1371/journal.pone.0147552. eCollection 2016.
9
Protecting against electrode insertion trauma using dexamethasone.使用地塞米松预防电极插入创伤。
Cochlear Implants Int. 2019 Jan;20(1):1-11. doi: 10.1080/14670100.2018.1509531. Epub 2018 Aug 20.
10
Growth factor-eluting cochlear implant electrode: impact on residual auditory function, insertional trauma, and fibrosis.生长因子缓释型人工耳蜗电极：对残余听觉功能、插入创伤和纤维化的影响。
J Transl Med. 2014 Oct 4;12:280. doi: 10.1186/s12967-014-0280-4.

引用本文的文献

1
Effects of Microstructured and Anti-Inflammatory-Coated Cochlear Implant Electrodes on Fibrous Tissue Growth and Neuronal Survival.微结构和抗炎涂层人工耳蜗电极对纤维组织生长和神经元存活的影响。
J Funct Biomater. 2025 Jan 18;16(1):33. doi: 10.3390/jfb16010033.
2
Outcomes following cochlear implantation with eluting electrodes: A systematic review.使用洗脱电极进行人工耳蜗植入后的结果：一项系统评价。
Laryngoscope Investig Otolaryngol. 2024 Jun 7;9(3):e1263. doi: 10.1002/lio2.1263. eCollection 2024 Jun.
3
Current Concepts and Future Trends in Increasing the Benefits of Cochlear Implantation: A Narrative Review.

本文引用的文献

1
Development of a rapidly made, easily personalized drug-eluting polymer film on the electrode array of a cochlear implant during surgery.在手术过程中，于耳蜗植入体的电极阵列上快速制作并可轻松定制的药物洗脱聚合物薄膜的开发。
Biochem Biophys Res Commun. 2020 May 28;526(2):328-333. doi: 10.1016/j.bbrc.2020.02.171. Epub 2020 Mar 24.
2
Short-term NAD supplementation prevents hearing loss in mouse models of Cockayne syndrome.短期补充烟酰胺腺嘌呤二核苷酸可预防科凯恩综合征小鼠模型的听力损失。
NPJ Aging Mech Dis. 2020 Jan 7;6:1. doi: 10.1038/s41514-019-0040-z. eCollection 2020.
3
Glucocorticoid for Hearing Preservation After Cochlear Implantation: A Systemic Review and Meta-analysis of Animal Studies.
当前增加人工耳蜗植入效益的概念和未来趋势：叙事性综述。
Medicina (Kaunas). 2022 May 31;58(6):747. doi: 10.3390/medicina58060747.
糖皮质激素在人工耳蜗植入后听力保护中的应用：动物研究的系统评价和荟萃分析。
Otol Neurotol. 2019 Oct;40(9):1178-1185. doi: 10.1097/MAO.0000000000002383.
4
[The progress of topical drug delivery to the inner ear for the inhibition of inflammation and fibrosis following cochlear implantation].[用于抑制人工耳蜗植入后炎症和纤维化的内耳局部给药进展]
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Jan 7;54(1):69-72. doi: 10.3760/cma.j.issn.1673-0860.2019.01.017.
5
A tonal-language benefit for pitch in normally-hearing and cochlear-implanted children.具有声调语言优势的正常听力和植入人工耳蜗儿童的音高感知。
Sci Rep. 2019 Jan 14;9(1):109. doi: 10.1038/s41598-018-36393-1.
6
Inner ear test battery in guinea pig models - a review.豚鼠模型中的内耳测试组合——综述
Acta Otolaryngol. 2018 Jun;138(6):519-529. doi: 10.1080/00016489.2017.1419576. Epub 2018 Jan 8.
7
NAD : A key metabolic regulator with great therapeutic potential.NAD：一种具有巨大治疗潜力的关键代谢调节剂。
J Neuroendocrinol. 2017 Oct;29(10). doi: 10.1111/jne.12508.
8
The Role of Preoperative Steroids in Atraumatic Cochlear Implantation Surgery.术前使用类固醇在无创伤性人工耳蜗植入手术中的作用
Otol Neurotol. 2017 Sep;38(8):1118-1124. doi: 10.1097/MAO.0000000000001505.
9
The Advances in Hearing Rehabilitation and Cochlear Implants in China.中国在听力康复和人工耳蜗植入方面的进展。
Ear Hear. 2017 Nov/Dec;38(6):647-652. doi: 10.1097/AUD.0000000000000441.
10
Prevention of trauma-induced cochlear fibrosis using intracochlear application of anti-inflammatory and antiproliferative drugs.通过鼓室内应用抗炎和抗增殖药物预防创伤性耳蜗纤维化
Neuroscience. 2016 Mar 1;316:261-78. doi: 10.1016/j.neuroscience.2015.12.031. Epub 2015 Dec 21.