Regulating influence of transferred immune spleen cells on the primary response of mice to sheep red blood cells.

The regulating influence of transferred immune spleen cells on the primary response of mice to sheep red blood cells (SRBC) was investigated. When splenic memory cells were intravenously inoculated, the greater part of these cells disappeared from the peripheral blood between 30 min and 6 h after injection. Transfer of immune spleen cells 2 days before immunization with 4 X 10(8) SRBC intravenously caused decreased numbers of PFC in the recipient spleen and up to 10 times as many PFC in the bone marrow. Apparently, the regulating influence of immune spleen cells upon antibody formation during the primary response can differ in different organs.