Axelrad M A
J Exp Med. 1971 Apr 1;133(4):857-63. doi: 10.1084/jem.133.4.857.
The acquisition of a capacity to respond well to sheep erythrocytes in the presence of anti-SRBC antibody was taken as an indication of the presence of immunological memory. By the use of passive immunization, both the primary IgG plaque-forming cell response and the establishment of memory were abolished, despite occurrence of a full peak IgM PFC response. Evidence for regarding the aquisition of memory and the IgM PFC and IgG PFC responses as three separate processes was presented. Antibody on day 3 of the response to 1.5 x 10(8) SRBC abolished formation of memory; this effect was less if passive immunization was further delayed and absent by day 10.
在存在抗绵羊红细胞（SRBC）抗体的情况下获得对绵羊红细胞良好反应的能力被视为免疫记忆存在的指标。通过被动免疫，尽管出现了完整的IgM斑块形成细胞（PFC）反应峰值，但原发性IgG PFC反应和记忆的建立均被消除。文中提供了将记忆的获得、IgM PFC反应和IgG PFC反应视为三个独立过程的证据。在对1.5×10⁸个SRBC反应的第3天，抗体消除了记忆的形成；如果被动免疫进一步延迟，这种效应会减弱，到第10天则不存在。
