Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Parkinsonism Relat Disord. 2021 Oct;91:9-12. doi: 10.1016/j.parkreldis.2021.08.009. Epub 2021 Aug 18.
Progressive supranuclear palsy (PSP) variants other than PSP-Richardson Syndrome (PSP-RS) have been recognized, including PSP with speech and language problems (PSP-SL). Given the reported sleep disruptions in PSP-RS, we investigated sleep abnormalities in PSP-SL.
Four sleep-related screening questions were given to the caregivers of 90 patients with PSP-SL (59 suggestive of PSP-SL and 31 possible PSP-SL) and 71 probable PSP-RS (prob. PSP-RS) patients.
At least one sleep-related disturbance was observed in 35.6% of suggestive of PSP-SL, 38.7% of possible PSP-SL, and 67.6% of prob. PSP-RS, the most common being "unable to fall or stay asleep". Prob. PSP-RS showed higher frequency of "screaming or talking in sleep", "acting out dreams", and "unable to fall or stay asleep" compared to both PSP-SL groups, but did not differ from possible PSP-SL in "excessive daytime sleepiness".
Sleep abnormalities are common in PSP-SL, but less frequent than prob.PSP-RS.
除了理查德森氏进行性核上麻痹（PSP-Richardson 综合征）以外，还已经认识到其他进行性核上麻痹变异型，包括伴有言语和语言问题的进行性核上麻痹（PSP-SL）。鉴于 PSP-RS 报告的睡眠障碍，我们研究了 PSP-SL 的睡眠异常。
向 90 名 PSP-SL 患者（59 名疑似 PSP-SL 和 31 名可能 PSP-SL）和 71 名可能的 PSP-RS 患者（prob. PSP-RS）的护理人员提供了 4 个与睡眠相关的筛查问题。
在疑似 PSP-SL 中，至少有一个睡眠相关障碍的患者占 35.6%，可能的 PSP-SL 中占 38.7%，prob. PSP-RS 中占 67.6%，最常见的是“无法入睡或保持睡眠”。与 PSP-SL 两组相比，prob. PSP-RS 表现出更高频率的“在睡眠中尖叫或说话”、“表现出梦境”和“无法入睡或保持睡眠”，但与可能的 PSP-SL 在“白天过度嗜睡”方面没有差异。
睡眠异常在 PSP-SL 中很常见，但比 prob.PSP-RS 少见。
