Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China; Zhongguancun Open Laboratory of the Research and Development of Natural Medicine and Health Products, Beijing 100193, China; Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100193, China.
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China; Zhongguancun Open Laboratory of the Research and Development of Natural Medicine and Health Products, Beijing 100193, China; Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100193, China.
Biomed Pharmacother. 2021 Oct;142:112074. doi: 10.1016/j.biopha.2021.112074. Epub 2021 Aug 20.
Heat shock proteins (HSPs) are a group of proteins, also known as molecular chaperones, which participate in protein folding and maturation in response to stresses or high temperature. According to their molecular weights, mammalian HSPs are classified into HSP27, HSP40, HSP60, HSP70, HSP90, and large HSPs. Previous studies have revealed that HSPs play important roles in oncogenesis and malignant progression because they can modulate all six hallmark traits of cancer. Because of this, HSPs have been propelled into the spotlight as biomarkers for cancer diagnosis and prognosis, as well as an exciting anticancer drug target. However, the relationship between the expression level of HSPs and their activity and cancer diagnosis, prognosis, metabolism and treatment is not clear and has not been completely established. Herein, this review summarizes and discusses recent advances and perspectives in major HSPs as biomarkers for cancer diagnosis, as regulators for cancer metabolism or as therapeutic targets for cancer therapy, which may provide new directions to improve the accuracy of cancer diagnosis and develop more effective and safer anticancer therapeutics.
热休克蛋白（HSPs）是一组蛋白质，也称为分子伴侣，它们在应激或高温下参与蛋白质折叠和成熟。根据它们的分子量，哺乳动物 HSPs 分为 HSP27、HSP40、HSP60、HSP70、HSP90 和大 HSPs。先前的研究表明，HSPs 在肿瘤发生和恶性进展中发挥重要作用，因为它们可以调节癌症的所有六个标志性特征。因此，HSPs 已成为癌症诊断和预后的生物标志物，以及令人兴奋的抗癌药物靶点。然而，HSPs 的表达水平与其活性以及癌症诊断、预后、代谢和治疗之间的关系尚不清楚，也尚未完全确立。在此，本文综述了 HSPs 作为癌症诊断的生物标志物、癌症代谢的调节剂或癌症治疗的治疗靶点的最新进展和观点，这可能为提高癌症诊断的准确性和开发更有效和更安全的抗癌疗法提供新的方向。
