Department of Molecular Oncology, Cancer Research Institute, Biomedical Research Center of Slovak Academy of Sciences, Dubravska cesta 9, 84505 Bratislava, Slovakia.
Department of Molecular Oncology, Cancer Research Institute, Biomedical Research Center of Slovak Academy of Sciences, Dubravska cesta 9, 84505 Bratislava, Slovakia.
Cell Signal. 2021 Nov;87:110120. doi: 10.1016/j.cellsig.2021.110120. Epub 2021 Aug 21.
In some types of human cancer, aldehyde dehydrogenases represent stemness markers and their expression is associated with advanced disease stages and poor prognosis. Although several biological functions are mediated by their product Retinoid acid, the molecular mechanism is tissue-dependent and only partially understood. In this review, we summarize the current knowledge about the role of ALDH in solid tumours, especially ALDH1A1 and ALDH1A3 isoforms, regarding the molecular mechanism of their transcription and regulation, and their crosstalk with main molecular pathways resulting in the excessive proliferation, chemoresistance, stem cells properties and invasiveness. The recent knowledge of the regulatory effect of lnRNA on ALDH1A1 and ALDH1A3 is discussed too.
在某些类型的人类癌症中，醛脱氢酶代表干细胞标志物，其表达与晚期疾病阶段和预后不良相关。尽管它们的产物视黄酸介导了几种生物学功能，但分子机制是组织依赖性的，并且仅部分了解。在这篇综述中，我们总结了目前关于 ALDH 在实体瘤中的作用的知识，特别是 ALDH1A1 和 ALDH1A3 同工型，涉及它们的转录和调节的分子机制，以及它们与主要分子途径的相互作用，导致过度增殖、化疗耐药、干细胞特性和侵袭性。还讨论了 lncRNA 对 ALDH1A1 和 ALDH1A3 的调节作用的最新知识。
