Górski Bartłomiej, Szerszeń Marcin, Kaczyński Tomasz
Department of Periodontology and Oral Mucosa Diseases, Medical University of Warsaw, Stanisława Binieckiego St 6, 02-097, Warsaw, Poland.
Department of Dental Prosthetics, Medical University of Warsaw, Stanisława Binieckiego St 6, 02-097, Warsaw, Poland.
Clin Oral Investig. 2022 Feb;26(2):1761-1772. doi: 10.1007/s00784-021-04151-9. Epub 2021 Aug 24.
To investigate effects of root conditioning with 24% ethylenediaminetetraacetic acid (EDTA) on the 12-month outcomes after treatment of multiple gingival recessions (GR) with modified coronally advanced tunnel (MCAT) and subepithelial connective tissue graft (SCTG).
Twenty patients with 142 GR were treated (72 test sites: SCTG + EDTA and 70 control sites: SCTG). Average and complete root coverage (ARC, CRC), gain in keratinized tissue width (KTW), gain in gingival thickness (GT), root esthetic coverage score (RES), and patient-reported outcome measures (PROMs) were evaluated at 12 months post-operatively.
Differences between pre- and post-operative values were statistically significant only within but not between treatment modalities. At 12 months, ARC was 86.0% for SCTG + EDTA-treated and 84.6 for SCTG-treated defects (p = 0.6636). CRC was observed in 90.2% (tests) and 91.4% (controls) of all cases (p = 0.9903). Professional assessment of esthetic outcomes using RES showed highly positive results reaching the value of 8.9 in case of test sites and 8.7 for control sites (p = 0.3358). Severity of pain and swelling did not differ between sites, regardless of whether EDTA was used.
Test and control sites presented similarly positive outcomes related to root coverage, periodontal and esthetic parameters, and patient satisfaction and self-reported morbidity with no statistical differences between them 12 months after surgery. No significant differences in evaluated variables were observed between sites treated with and without 24% EDTA. Clinical relevance Considering the limitations of the present study, the use of 24% EDTA for root conditioning did not improve 12-month outcomes after treatment of multiple RT1 and RT2 gingival recessions with MCAT and SCTG. Trial registration ClinicalTrials.gov identifier: NCT03354104.
探讨用24%乙二胺四乙酸（EDTA）进行牙根预处理对改良冠向推进隧道术（MCAT）和上皮下结缔组织移植术（SCTG）治疗多处牙龈退缩（GR）后12个月疗效的影响。
对20例患有142处牙龈退缩的患者进行治疗（72个试验部位：SCTG + EDTA；70个对照部位：SCTG）。术后12个月评估平均和完全牙根覆盖（ARC、CRC）、角化组织宽度增加量（KTW）、牙龈厚度增加量（GT）、牙根美学覆盖评分（RES）以及患者报告的结局指标（PROMs）。
术前和术后值之间的差异仅在治疗方式内部具有统计学意义，而在不同治疗方式之间无统计学意义。术后12个月，SCTG + EDTA治疗的缺损部位ARC为86.0%，SCTG治疗的缺损部位为84.6%（p = 0.6636）。所有病例中，90.2%（试验组）和91.4%（对照组）观察到完全牙根覆盖（p = 0.9903）。使用RES对美学效果进行专业评估显示，试验部位的结果非常积极，评分为8.9，对照部位为8.7（p = 0.3358）。无论是否使用EDTA，各部位疼痛和肿胀的严重程度均无差异。
试验组和对照组在牙根覆盖、牙周和美学参数以及患者满意度和自我报告的发病率方面均呈现出相似的积极结果，术后12个月两者之间无统计学差异。在使用和未使用24% EDTA治疗的部位之间，未观察到评估变量的显著差异。临床相关性 考虑到本研究的局限性，用24% EDTA进行牙根预处理并不能改善MCAT和SCTG治疗多处RT1和RT2牙龈退缩后12个月的疗效。试验注册 ClinicalTrials.gov标识符：NCT03354104。
