Owens W, Henley F, Barridge B D
J Clin Microbiol. 1978 Feb;7(2):153-7. doi: 10.1128/jcm.7.2.153-157.1978.
Hemolytic mutants of Lancefield strain SS-95 and ATCC 19615 Streptococcus pyogenes were produced by treatment with N-methyl-N'-nitro-N-nitrosoguanidine. These mutants contained the same levels of streptolysin O, nicotinamide adenine dinucleotidase, deoxyribonuclease, and hyaluronidase. The mutants were deficient in streptolysin S, as was the naturally occurring nonhemolytic Lowry strain. The mutants retained their pathogenicity for mice and, when reisolated from the dead animals, produced the mutant hemolytic pattern.
用N-甲基-N'-硝基-N-亚硝基胍处理，产生了兰斯菲尔德SS-95株和ATCC 19615化脓性链球菌的溶血突变体。这些突变体含有相同水平的链球菌溶血素O、烟酰胺腺嘌呤二核苷酸酶、脱氧核糖核酸酶和透明质酸酶。这些突变体缺乏链球菌溶血素S，天然存在的非溶血劳里菌株也是如此。这些突变体对小鼠仍具有致病性，当从死亡动物中重新分离时，会产生突变的溶血模式。
