MRL-lpr/lpr小鼠表现出IgG聚集体清除功能受损，这与疾病活动参数相关。
MRL-lpr/lpr mice show an impairment of IgG aggregate removal which relates to parameters of disease activity.
作者信息
Field M, Brennan F M, McCarthy D, Mumford P, Maini R N
机构信息
Clinical Immunology Division, Kennedy Institute of Rheumatology, Hammersmith, London, U.K.
出版信息
Immunology. 1987 Aug;61(4):463-7.
Abstract
MRL-lpr/lpr mice show an age-related impairment in the removal of heat-aggregated IgG (HAGG) from the circulation. The female mice, which have an earlier mortality than their male counterparts, clear HAGG more slowly than the male animals. Delay in clearance of this probe of mononuclear phagocytic system (MPS) function relates directly to high levels of circulating immune complexes (CIC) and to significant renal damage. In addition it relates indirectly to hepatic and splenic uptake of HAGG. MPS saturation plays a significant role in the pathogenesis of the disease seen in MRL-lpr/lpr mice.
摘要
MRL-lpr/lpr小鼠在从循环中清除热聚集IgG（HAGG）方面表现出与年龄相关的损害。雌性小鼠的死亡率比雄性小鼠更早，清除HAGG的速度比雄性动物更慢。这种单核吞噬细胞系统（MPS）功能指标清除的延迟与循环免疫复合物（CIC）的高水平以及显著的肾损伤直接相关。此外，它还与肝脏和脾脏对HAGG的摄取间接相关。MPS饱和在MRL-lpr/lpr小鼠所患疾病的发病机制中起重要作用。
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