Kolaja G J, Fast P E
Vet Pathol. 1982 Nov;19(6):663-8. doi: 10.1177/030098588201900611.
Female MRL-Mp-lpr/lpr mice spontaneously develop autoimmune disease at three to five months of age and die most commonly from immune complex glomerulonephritis. Kidneys of two-month-old females appeared nearly normal by electron microscopy, and glomerular deposits of IgG an complement component 3 (C3) barely were detectable. In five-month-old females, immunofluorescence revealed numerous deposits of IgG and C3; glomerular mesangial cells were hypertrophic and hyperplastic and contained electron-dense material. There were subepithelial and subendothelial deposits of electron-dense material with swelling of epithelial cell cytoplasm. This disease has many features similar to the immune complex glomerulonephritis observed in New Zealand Black and White hybrid mice and in man.
雌性MRL-Mp-lpr/lpr小鼠在3至5月龄时会自发患上自身免疫性疾病，最常见的死因是免疫复合物性肾小球肾炎。通过电子显微镜观察，2月龄雌性小鼠的肾脏几乎正常，IgG和补体成分3（C3）的肾小球沉积物几乎检测不到。在5月龄雌性小鼠中，免疫荧光显示有大量IgG和C3沉积物；肾小球系膜细胞肥大且增生，并含有电子致密物质。上皮细胞和内皮细胞下有电子致密物质沉积，上皮细胞胞质肿胀。这种疾病有许多特征与在新西兰黑白杂交小鼠和人类中观察到的免疫复合物性肾小球肾炎相似。
