Gong Jianguang, Zhan Huifang, Liang Yan, He Qiang, Cui Dawei
Department of Nephrology, Nephrology Center, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, China.
Department of Emergency, Zhejiang University Hospital, Hangzhou, China.
Front Med (Lausanne). 2021 Aug 9;8:708140. doi: 10.3389/fmed.2021.708140. eCollection 2021.
Naive CD4 T cells can differentiate into different cell subsets after receiving antigen stimulation, which secrete corresponding characteristic cytokines and thereby exert biological effects in various diseases. Th22 cells, a novel subset of CD4 T cells, are different from Th1, Th2, Th17, and Treg cell subsets, which have been discovered in recent years. They can express CCR4, CCR6, and CCR10 molecules and secrete IL-22, IL-13, and TNF-α. They are not able to secrete IL-17, IL-4, and interferon-γ (IFN-γ). IL-22 is considered as a major effector molecule of Th22 cells whose functions and mechanisms of regulating cell differentiation have been constantly improved. In this review, we provide an overview of the origin, differentiation of Th22 cells. Moreover, we also describe the interrelationships between Th22 cells and Th17, Th1, and Th2 cells. Additionally, the role of Th22 cells were discussed in human diseases with virus infection, which will provide novel insight for the prevention and treatment of viral infection in human.
初始CD4 T细胞在接受抗原刺激后可分化为不同的细胞亚群，这些亚群分泌相应的特征性细胞因子，从而在各种疾病中发挥生物学作用。Th22细胞是近年来发现的一种新型CD4 T细胞亚群，不同于Th1、Th2、Th17和Treg细胞亚群。它们可表达CCR4、CCR6和CCR10分子，并分泌IL-22、IL-13和TNF-α。它们不能分泌IL-17、IL-4和干扰素-γ（IFN-γ）。IL-22被认为是Th22细胞的主要效应分子，其调节细胞分化的功能和机制一直在不断完善。在这篇综述中，我们概述了Th22细胞的起源、分化。此外，我们还描述了Th22细胞与Th17、Th1和Th2细胞之间的相互关系。此外，还讨论了Th22细胞在人类病毒感染性疾病中的作用，这将为人类病毒感染的预防和治疗提供新的见解。
