Department of Internal Medicine, Centre of Excellence for Biomedical Research, University of Genoa, Genoa, Italy.
Biotherapy Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
J Med Virol. 2021 Sep;93(9):5608-5613. doi: 10.1002/jmv.27037. Epub 2021 May 3.
In this observational study, 13 patients with severe COVID-19 and 10 healthy controls were enrolled. The data concerning the analysis of circulating T cells show that, in severe COVID-19 patients, the expansion of these cell compartments is prone to induce antibody response, inflammation (CCR4+ and CCR6+ TFH) and regulation (CD8+ Treg). This pathogenic mechanism could lead us to envision a possible new form of biological target therapy.
在这项观察性研究中，纳入了 13 名重症 COVID-19 患者和 10 名健康对照者。有关循环 T 细胞分析的数据表明，在重症 COVID-19 患者中，这些细胞区室的扩增容易诱导抗体反应、炎症（CCR4+和 CCR6+TFH）和调节（CD8+Treg）。这种发病机制可能使我们设想一种新的潜在生物靶标治疗形式。
