Department of Cardiology Surgery, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian, Jiangsu Province 223001, China.
Department of Cardiology Surgery, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian, Jiangsu Province 223001, China.
Int Immunopharmacol. 2021 Oct;99:108041. doi: 10.1016/j.intimp.2021.108041. Epub 2021 Aug 11.
CD14 is crucial in the progression of myocardial infarction (MI). Several studies have explored the association between the risk of MI and the CD14 C-260 T polymorphism, but have reported inconsistent results.
This study analyzed the association of the CD14 C-260 T polymorphism with susceptibility to MI. Totally, 240 MI patients and 298 normal subjects were included. The association between MI risk and the target polymorphism was assessed using 95% confidence intervals and odds ratios obtained through logistic regression.
The T allele of the CD14 C-260 T polymorphism was linked with an elevated risk of MI in Chinese Han people; subgroup analysis indicated that this effect was associated with smoking, male gender, and hypertension. In addition, the data revealed that different genotype carriers of the CD14 C-260 T polymorphism showed significantly distinct TG levels in MI patients.
Totally, the T allele of the CD14 C-260 T polymorphism is associated with an elevated risk of MI.
CD14 在心肌梗死（MI）的进展中起着关键作用。有几项研究探讨了 MI 风险与 CD14 C-260T 多态性之间的关系，但结果不一致。
本研究分析了 CD14 C-260T 多态性与 MI 易感性的关系。共纳入 240 例 MI 患者和 298 例正常对照。通过 logistic 回归获得的 95%置信区间和优势比评估 MI 风险与目标多态性之间的关联。
CD14 C-260T 多态性的 T 等位基因与中国汉族人群 MI 风险升高相关；亚组分析表明，这种效应与吸烟、男性和高血压有关。此外，数据显示，MI 患者中 CD14 C-260T 多态性不同基因型携带者的 TG 水平存在显著差异。
总的来说，CD14 C-260T 多态性的 T 等位基因与 MI 风险升高相关。
