Department of Clinical Sciences Lund, Dermatology and Venereology, Lund University, Skane University Hospital, SE-221 85 Lund, Sweden.
Acta Derm Venereol. 2021 Sep 3;101(9):adv00539. doi: 10.2340/00015555-3912.
Prurigo simplex or "itchy red bump" disease is a controversial pruritic papular eruption. The objective of this study was to delineate the diagnostic criteria for this disease. A PubMed search was performed for: "prurigo simplex", "prurigo simplex subacuta", "subacute prurigo", "chronic papular dermatitis in adults" and "itchy red bump disease". Medical charts of patients with prurigo diagnoses in a university setting were analysed. The literature search revealed 32 relevant studies (431 patients) on different aspects of the disease. Out of 50 patients with prurigo diagnoses, 5 patients (4 women, mean age at onset 54 years) matched the description in literature. Small, severely itchy papules without secondary skin lesions continued to appear for years (mean 5.6 years). Skin biopsies revealed lymphocytic perivascular infiltrates, few eosinophils and occasionally spongiosis. Treatment with long-term metho-trexate or cyclosporine cleared the symptoms. Some major and minor diagnostic criteria for prurigo simplex are proposed and compared with chronic prurigo.
单纯性瘙痒症或“瘙痒性红色丘疹”病是一种有争议的瘙痒性丘疹性发疹。本研究的目的是描述该疾病的诊断标准。在 PubMed 上进行了以下搜索：“单纯性瘙痒症”、“亚急性单纯性瘙痒症”、“亚急性瘙痒症”、“成人慢性丘疹性皮炎”和“瘙痒性红色丘疹病”。对大学环境中患有瘙痒症诊断的患者的病历进行了分析。文献检索显示，有 32 项关于该疾病不同方面的相关研究（431 名患者）。在 50 名患有瘙痒症诊断的患者中，有 5 名患者（4 名女性，发病时的平均年龄为 54 岁）符合文献中的描述。小而剧烈瘙痒的丘疹，无继发性皮肤病变，持续多年（平均 5.6 年）出现。皮肤活检显示淋巴细胞血管周围浸润，嗜酸性粒细胞较少，偶尔出现海绵形成。长期使用甲氨蝶呤或环孢素治疗可清除症状。提出了单纯性瘙痒症的一些主要和次要诊断标准，并与慢性瘙痒症进行了比较。
