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手术干预和治疗药物难治性心肌桥的结果。

Surgical intervention and outcome for treatment of myocardial bridging refractory to medication.

机构信息

Department of Cardiac Surgery, First Hospital of Tsinghua University, Beijing, China.

出版信息

J Card Surg. 2021 Nov;36(11):4068-4074. doi: 10.1111/jocs.15941. Epub 2021 Aug 26.

DOI:10.1111/jocs.15941
PMID:34437726
Abstract

INTRODUCTION

Myocardial bridging (MB) is a common and usually benign inborn coronary abnormality that may lead to anginal symptoms, acute coronary syndrome, arrhythmias, and rarely sudden cardiac death. MB are most commonly localized in the middle segment of the left anterior descending coronary artery (LAD). The treatment of LAD-MB is still challenging. Our objective was to assess the short- and long-term results of surgical procedures in patients with LAD-MB who had chest pain refractory to medical therapy.

METHODS

Between March 2005 and January 2020, 26 patients (19 males and 7 females; mean 55.8 ± 12.4 years) with MB underwent surgery. All MB was located in the mid-segment of the LAD with a mean length of 4.2 ± 1.7 cm. Coronary angiography before surgery demonstrated LAD-MB with systolic compression more than or equal to 70% in all patients.

RESULTS

Twenty-five patients underwent myotomy and one patient underwent coronary artery bypass grafting (CABG). All patients survived and recovered uneventfully. Neither hospital or late death nor major complications occurred. Follow-up time was 3-173 months (mean 55.7 months). Follow-up of coronary angiography or computed tomography scan performed in 16 patients demonstrated restoration of coronary blood flow and myocardial perfusion without significant residual compression of the artery. All patients were symptom-free and are currently in NYHA Class I.

CONCLUSION

The symptomatic LAD-MB patients who are refractory to medication should actively undergo the surgical intervention such as myotomy and CABG to eliminate the clinical symptoms and achieve satisfactory results by follow-up findings. Myotomy is a preferred procedure because of its safety and satisfactory results.

摘要

简介

心肌桥(MB)是一种常见且通常良性的先天性冠状动脉异常,可能导致心绞痛症状、急性冠状动脉综合征、心律失常,极少数情况下还会导致心源性猝死。MB 最常位于左前降支冠状动脉(LAD)的中段。LAD-MB 的治疗仍然具有挑战性。我们的目的是评估药物治疗无效的 LAD-MB 患者接受手术治疗的短期和长期效果。

方法

2005 年 3 月至 2020 年 1 月,26 例(男 19 例,女 7 例;平均年龄 55.8±12.4 岁)MB 患者接受了手术治疗。所有 MB 均位于 LAD 中段,平均长度为 4.2±1.7cm。所有患者术前冠状动脉造影均显示 LAD-MB,收缩期压迫≥70%。

结果

25 例行心肌切开术,1 例行冠状动脉旁路移植术(CABG)。所有患者均存活并顺利康复。无院内或晚期死亡,无重大并发症发生。随访时间为 3-173 个月(平均 55.7 个月)。对 16 例患者进行的冠状动脉造影或计算机断层扫描随访显示,冠状动脉血流和心肌灌注得到恢复,动脉无明显残余压迫。所有患者均无症状,目前心功能分级为 NYHA I 级。

结论

药物治疗无效的症状性 LAD-MB 患者应积极接受手术干预,如心肌切开术和 CABG,以消除临床症状,并通过随访结果获得满意的效果。由于其安全性和满意的效果,心肌切开术是一种首选的手术方法。

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