Departmento de Nutrición y Bromatología, Universidad de Granada, Campus de Melilla, Spain; I Instituto de Nutrición y Tecnología de los Alimentos 'José Mataix', Universidad de Granada, Granada, Spain; Instituto de Investigación Biosanitaria de Granada ibs.GRANADA, Spain.
Instituto de Investigación Biosanitaria de Granada ibs.GRANADA, Spain; Unidad de Gestión Clínica de Farmacia Hospitalaria, Hospital Universitario San Cecilio, Granada, Spain.
Environ Pollut. 2021 Oct 1;286:117496. doi: 10.1016/j.envpol.2021.117496. Epub 2021 Jun 2.
The aim of this work was to study the associations of adipose tissue trace element concentrations with type 2 diabetes (T2DM) incidence over a 16-year follow-up period in an adult cohort from Southern Spain. 16-year T2DM incidence was gathered from hospital records. Chemical analyses of Cr, V, Zn, Fe, Cu and Se in adipose tissue were performed using inductively coupled plasma mass spectrometry. Multivariable Cox-regression models were used. Complementary cross-sectional analyses with markers of glucose homeostasis at recruitment were performed by multivariable linear regression. Out of 214 participants, 39 developed T2DM during the follow-up. Adipose tissue concentrations of Fe (HR = 1.97, 95% CI: 0.99 to 2.58, p = 0.057), Cr (HR = 1.58, 95% CI: 1.07-2.33, p = 0.022) and Cu (HR = 1.61, 95% CI: 1.01-2.58, p = 0.046) were individually associated with T2DM incidence. When Fe, Cr and Cu were simultaneously entered in a model, only Cr was significantly associated with T2DM incidence (HR = 1.68, 95% CI: 1.02-2.76, p = 0.041). Furthermore, adipose tissue V (β = 0.283, p = 0.004) and Zn (β = 0.217, p = 0.028) concentrations were positively associated with β-pancreatic cell function (HOMA-β), while Se showed an inverse association (β = -0.049, p = 0.027). Although further research is warranted on the potential mechanisms of action, our results suggest that adipose tissue concentrations of certain trace elements (particularly Fe, Cr and Cu) are associated with the risk of incident T2DM, while V and Zn might have a protective effect. These biomarkers might complement prediction algorithms and contribute to identify patients with an increased risk of T2DM.
本研究旨在通过对西班牙南部成年人队列的 16 年随访，研究脂肪组织微量元素浓度与 2 型糖尿病（T2DM）发病之间的关联。通过医院记录收集 16 年 T2DM 的发病率。使用电感耦合等离子体质谱法对脂肪组织中的 Cr、V、Zn、Fe、Cu 和 Se 进行化学分析。采用多变量 Cox 回归模型。通过多变量线性回归对招募时葡萄糖稳态标志物进行补充性横截面分析。在 214 名参与者中，有 39 名在随访期间发生了 T2DM。脂肪组织中 Fe（HR=1.97，95%CI：0.99 至 2.58，p=0.057）、Cr（HR=1.58，95%CI：1.07-2.33，p=0.022）和 Cu（HR=1.61，95%CI：1.01-2.58，p=0.046）的浓度与 T2DM 的发病风险独立相关。当将 Fe、Cr 和 Cu 同时纳入模型时，只有 Cr 与 T2DM 的发病风险显著相关（HR=1.68，95%CI：1.02-2.76，p=0.041）。此外，脂肪组织 V（β=0.283，p=0.004）和 Zn（β=0.217，p=0.028）浓度与 β-胰岛细胞功能（HOMA-β）呈正相关，而 Se 呈负相关（β=-0.049，p=0.027）。尽管需要进一步研究这些元素的潜在作用机制，但我们的结果表明，某些脂肪组织微量元素（特别是 Fe、Cr 和 Cu）的浓度与 T2DM 的发病风险相关，而 V 和 Zn 可能具有保护作用。这些生物标志物可能会补充预测算法，并有助于识别 T2DM 风险增加的患者。
