Wolide Amare Desalegn, Zawdie Belay, Alemayehu Tilahun, Tadesse Samuel
Department of Medical Physiology, College of Health Sciences, Jimma University, 378, Jimma, Ethiopia.
Department of Medical Biochemistry, College of Health Sciences, Jimma University, 378, Jimma, Ethiopia.
BMC Endocr Disord. 2017 Oct 13;17(1):64. doi: 10.1186/s12902-017-0217-z.
It is well known that dyslipidemia and chronic hyperglycemia increase the onset of diabetes and diabetic complication. The aim of this study is to see the association of trace metals elements and lipid profile among type 2 diabetes mellitus patients.
The study was conducted on 214 type 2 diabetic patients at Jimma University Specialized Hospital, Jimma, Ethiopia. All the eligible study participants responded to the structured interviewer administered questionnaire and fasting venous blood was drawn for biochemical analysis. Trace metal elements (zinc(Zn), magnesium(Mg), chromium(Cr), calcium(Ca), phosphorus(Po), manganese(Mn), copper(Cu), and iron(Fe)) and lipid profiles (total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein (HDL-C), and triglycerides (TG)) were measured by atomic absorption spectrophotometry and enzymatic determination method respectively. Data were analyzed by SPSS version 24 software for windows. Bonferroni correction for multiple statistical comparisons was used and a p-value less than 0.01 were accepted as a level of significance.
The mean age of study participants was 42.95(±12.6) with an average of 5.83(±3.1) years being diagnosed with diabetes mellitus. The BMI of female (27.1(±4.9)) was significantly higher than male (25.21(±4.2)). BMI shows positive and significant (p < 0.01) association with lipid profiles (TC, LDL-C, and TG) among type 2 diabetic patients in the liner regression model. In addition, WH-R was positively associated with TG. In Pearson partial correlation adjusted for sex and age, Za shown to have statistically significant and negative correlations with TC, LDL-C and with TG. Mg and Cr negatively and significantly correlated with the lipid profile TC and LDL-C. Ca negatively correlated with TC and TG. Po positively correlated with HDL-C; iron negatively correlated with TC. However, in the liner regression model, only calcium positively and significantly (Beta = -0.21, p < 0.01) associated with TG.
In the current study, a negative correlation was observed between trace metal elements (Zn, Mg, Cr, Ca and Fe) and lipid profile (TC, LDL-C and TG) among type 2 diabetes mellitus patients. In addition, Ca observed to be associated with TG. Future studies are highly advised to uncover the bidirectional association between trace metal element and dyslipidemia in diabetic patients.
众所周知，血脂异常和慢性高血糖会增加糖尿病及糖尿病并发症的发病风险。本研究旨在观察2型糖尿病患者体内微量元素与血脂水平之间的关联。
本研究在埃塞俄比亚吉马的吉马大学专科医院对214例2型糖尿病患者进行。所有符合条件的研究参与者均回答了由 interviewer 管理的结构化问卷，并采集空腹静脉血进行生化分析。分别采用原子吸收分光光度法和酶法测定微量元素（锌（Zn）、镁（Mg）、铬（Cr）、钙（Ca）、磷（Po）、锰（Mn）、铜（Cu）和铁（Fe））和血脂指标（总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白（HDL-C）和甘油三酯（TG））。数据采用windows版SPSS 24软件进行分析。采用Bonferroni校正进行多重统计比较，p值小于0.01被认为具有统计学意义。
研究参与者的平均年龄为42.95（±12.6）岁，平均糖尿病诊断时间为5.83（±3.1）年。女性的BMI（27.1（±4.9））显著高于男性（25.21（±4.2））。在直线回归模型中，2型糖尿病患者的BMI与血脂指标（TC, LDL-C和TG）呈正相关且具有统计学意义（p < 0.01）。此外，腰臀比与TG呈正相关。在经性别和年龄校正的Pearson偏相关分析中，锌与TC、LDL-C和TG呈显著负相关。镁和铬与血脂指标TC和LDL-C呈显著负相关。钙与TC和TG呈负相关。磷与HDL-C呈正相关；铁与TC呈负相关。然而，在直线回归模型中，只有钙与TG呈正相关且具有统计学意义（β = -0.21, p < 0.01）。
在本研究中，2型糖尿病患者体内微量元素（锌、镁、铬、钙和铁）与血脂指标（TC、LDL-C和TG）之间存在负相关。此外，钙与TG有关联。强烈建议未来的研究揭示糖尿病患者体内微量元素与血脂异常之间的双向关联。
