Nishimura T, Tabuki K, Motohiro T, Shimada Y, Takajo N, Nagayama K, Araki H, Iwai N, Miyatsu M, Nakamura H
Department of Pediatrics, Osaka Medical College.
Jpn J Antibiot. 1987 Nov;40(11):1881-90.
The authors administered cefotaxime to 20 children and studied laboratory parameters concerning peripheral blood: hemoglobin count, blood platelet count, red blood cell count, and hematocrit value, and the coagulation system: protein induced by vitamin K deficiency or by the presence of a vitamin K antagonist II (PIVKA II), hepaplastin test (HPT), prothrombin time (PT) and active partial thromboplastin time (APTT). The results obtained are summarized as follows: 1. Peripheral blood No abnormal values were observed. 2. Coagulation system (1) PIVKA II: In all cases, PIVKA II was negative. (2) HPT, PT and APTT: In all cases, no significant changes of these values which would suggest the tendency for prolonged bleeding were observed.
作者对20名儿童使用了头孢噻肟，并研究了有关外周血的实验室参数：血红蛋白计数、血小板计数、红细胞计数和血细胞比容值，以及凝血系统：维生素K缺乏或存在维生素K拮抗剂II诱导的蛋白（PIVKA II）、肝促凝血酶原激酶试验（HPT）、凝血酶原时间（PT）和活化部分凝血活酶时间（APTT）。获得的结果总结如下：1. 外周血 未观察到异常值。2. 凝血系统 （1）PIVKA II：在所有病例中，PIVKA II均为阴性。（2）HPT、PT和APTT：在所有病例中，未观察到这些值有显著变化，提示有出血时间延长的倾向。
