Kaneko H, Shirai T, Katoh M, Shimura H, Nojima Z, Senzui N
Jpn J Antibiot. 1985 Nov;38(11):3145-55.
Twenty infectious episodes were caused mainly by Gram-negative rods in 16 patients with a disorder of the hemopoietic tissue. The ages of the patients ranged between 20 and 76 years. Cefotaxime (CTX) was used alone in 9 infectious episodes (group I) and in combination with other antibiotics in the remaining 11 infectious episodes (group II). The following results were obtained. A good response to CTX was noted. The clinical and bacteriological success rates were 100% and 83% in group I, and 82% and 100% in group II, respectively. Bleeding was not clinically found during and after treatment of any infectious episodes with CTX. No change in PT and aPTT was noted during CTX treatment, either. CTX was thus evaluated to be an effective and safe cephem antibiotic in the treatment of infectious episodes secondary to a disorder of the hemopoietic tissue, which is usually accompanied by a marked hemorrhagic tendency.
16例造血组织疾病患者发生了20次感染发作，主要由革兰氏阴性杆菌引起。患者年龄在20至76岁之间。9次感染发作单独使用头孢噻肟（CTX）（I组），其余11次感染发作联合使用其他抗生素（II组）。得到以下结果。观察到对CTX有良好反应。I组临床和细菌学成功率分别为100%和83%，II组分别为82%和100%。在用CTX治疗任何感染发作期间及之后，临床上均未发现出血情况。在CTX治疗期间，PT和aPTT也未发现变化。因此，CTX被评估为治疗继发于造血组织疾病的感染发作的一种有效且安全的头孢菌素抗生素，造血组织疾病通常伴有明显的出血倾向。
