循环 microRNAs 从分子机制到临床生物标志物：以透明细胞肾细胞癌为例。
Circulating microRNAs from the Molecular Mechanisms to Clinical Biomarkers: A Focus on the Clear Cell Renal Cell Carcinoma.
机构信息
Department of Anatomical, Histological, Forensic & Orthopedic Sciences, Section of Histology & Medical Embryology, Sapienza University of Rome, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, 00161 Rome, Italy.
Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy.
出版信息
Genes (Basel). 2021 Jul 28;12(8):1154. doi: 10.3390/genes12081154.
Abstract
microRNAs (miRNAs) are emerging as relevant molecules in cancer development and progression. MiRNAs add a post-transcriptional level of control to the regulation of gene expression. The deregulation of miRNA expression results in changing the molecular circuitry in which miRNAs are involved, leading to alterations of cell fate determination. In this review, we describe the miRNAs that are emerging as innovative molecular biomarkers from liquid biopsies, not only for diagnosis, but also for post-surgery management in cancer. We focus our attention on renal cell carcinoma, in particular highlighting the crucial role of circulating miRNAs in clear cell renal cell carcinoma (ccRCC) management. In addition, the functional deregulation of miRNA expression in ccRCC is also discussed, to underline the contribution of miRNAs to ccRCC development and progression, which may be relevant for the identification and design of innovative clinical strategies against this tumor.
摘要
微小 RNA（miRNA）在癌症的发生和发展中是相关的分子。miRNA 在基因表达的调控上增加了转录后的调控水平。miRNA 表达的失调导致 miRNA 参与的分子电路发生改变，导致细胞命运决定的改变。在这篇综述中，我们描述了从液体活检中出现的作为创新分子生物标志物的 miRNA，不仅用于诊断，而且用于癌症手术后的管理。我们将注意力集中在肾细胞癌上，特别强调了循环 miRNA 在透明细胞肾细胞癌（ccRCC）管理中的关键作用。此外，还讨论了 miRNA 表达在 ccRCC 中的功能失调，以强调 miRNA 对 ccRCC 发生和发展的贡献，这可能与鉴定和设计针对这种肿瘤的创新临床策略有关。
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