Anatomy, School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, H91 W5P7 Galway, Ireland.
Regenerative Medicine Institute, National University of Ireland Galway, H91 TK33 Galway, Ireland.
Cells. 2021 Aug 16;10(8):2102. doi: 10.3390/cells10082102.
Spinal cord injury (SCI) is a devastating trauma that can cause permanent disability, life-long chronic issues for sufferers and is a big socioeconomic burden. Regenerative medicine aims to overcome injury caused deficits and restore function after SCI through gene therapy and tissue engineering approaches. SCI has a multifaceted pathophysiology. Due to this, producing therapies that target multiple different cellular and molecular mechanisms might prove to be a superior approach in attempts at regeneration. Both biomaterials and nucleic acid delivery via lentiviral vectors (LVs) have proven to promote repair and restoration of function post SCI in animal models. Studies indicate that a combination of biomaterials and LVs is more effective than either approach alone. This review presents studies supporting the use of LVs and LVs delivered with biomaterials in therapies for SCI and summarises methods to combine LVs with biomaterials for SCI treatment. By summarising this knowledge this review aims to demonstrate how LV delivery with biomaterials can augment/compliment both LV and biomaterial therapeutic effects in SCI.
脊髓损伤（SCI）是一种破坏性的创伤，可导致永久性残疾，给患者带来终身慢性问题，并造成巨大的社会经济负担。再生医学旨在通过基因治疗和组织工程方法来克服 SCI 引起的损伤并恢复功能。SCI 具有多方面的病理生理学。因此，产生针对多种不同细胞和分子机制的治疗方法可能在再生尝试中被证明是一种优越的方法。生物材料和通过慢病毒载体（LVs）的核酸传递都已被证明可促进动物模型 SCI 后的修复和功能恢复。研究表明，生物材料和 LVs 的组合比单独使用任何一种方法都更有效。本综述介绍了支持在 SCI 治疗中使用 LVs 和用生物材料传递 LVs 的研究，并总结了将 LVs 与生物材料结合用于 SCI 治疗的方法。通过总结这些知识，本综述旨在展示生物材料与 LVs 传递相结合如何增强/补充 SCI 中 LVs 和生物材料治疗效果。
