Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430060, China.
Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430060, China.
Int J Biol Macromol. 2023 Mar 1;230:123447. doi: 10.1016/j.ijbiomac.2023.123447. Epub 2023 Jan 26.
Spinal cord injury (SCI)-related disabilities are a serious problem in the modern society. Further, the treatment of SCI is highly challenging and is urgently required in clinical practice. Research on nerve tissue engineering is an emerging approach for improving the treatment outcomes of SCI. Chitosan (CS) is a cationic polysaccharide derived from natural biomaterials. Chitosan has been found to exhibit excellent biological properties, such as nontoxicity, biocompatibility, biodegradation, and antibacterial activity. Recently, chitosan-based biomaterials have attracted significant attention for SCI repair in nerve tissue engineering applications. These studies revealed that chitosan-based biomaterials have various functions and mechanisms to promote SCI repair, such as promoting neural cell growth, guiding nerve tissue regeneration, delivering nerve growth factors, and as a vector for gene therapy. Chitosan-based biomaterials have proven to have excellent potential for the treatment of SCI. This review aims to introduce the recent advances in chitosan-based biomaterials for SCI treatment and to highlight the prospects for further application.
脊髓损伤（SCI）相关残疾是现代社会的一个严重问题。此外，SCI 的治疗极具挑战性，在临床实践中迫切需要新的治疗方法。神经组织工程的研究是改善 SCI 治疗效果的新兴方法。壳聚糖（CS）是一种从天然生物材料中提取的阳离子多糖。壳聚糖具有无毒、生物相容性、可生物降解和抗菌活性等优异的生物学特性。最近，壳聚糖基生物材料在神经组织工程应用中对 SCI 修复引起了广泛关注。这些研究表明，壳聚糖基生物材料具有多种功能和机制来促进 SCI 修复，例如促进神经细胞生长、引导神经组织再生、递送神经营养因子以及作为基因治疗的载体。壳聚糖基生物材料在治疗 SCI 方面具有巨大的潜力。本综述旨在介绍壳聚糖基生物材料在 SCI 治疗方面的最新进展，并强调其进一步应用的前景。
