LAQV-REQUIMTE, Chemistry Department, NOVA School of Science and Technology, NOVA University of Lisbon, 2825-149 Caparica, Portugal.
Associate Laboratory i4HB-Institute for Health and Bioeconomy, School of Science and Technology, NOVA University Lisbon, 2815-149 Caparica, Portugal.
Molecules. 2021 Aug 6;26(16):4772. doi: 10.3390/molecules26164772.
In this work, we propose the utilization of scCO to impregnate ibuprofen into the mcl-PHA matrix produced by subs. (DSM 19603). The biopolymer has adhesive properties, is biocompatible and has a melting temperature of 45 °C. Several conditions, namely, pressure (15 and 20 MPa) and impregnation time (30 min, 1 h and 3 h) were tested. The highest ibuprofen content (90.8 ± 6.5 mg of ibuprofen/g) was obtained at 20 MPa and 40 °C, for 1 h, with an impregnation rate of 89 mg/(g·h). The processed mcl-PHA samples suffered a plasticization, as shown by the decrease of 6.5 °C in the T, at 20 MPa. The polymer's crystallinity was also affected concomitantly with the matrices' ibuprofen content. For all the impregnation conditions tested the release of ibuprofen from the biopolymer followed a type II release profile. This study has demonstrated that the mcl-PHA produced by has a great potential for the development of novel topical drug delivery systems.
在这项工作中，我们提出利用超临界二氧化碳（scCO2）将布洛芬注入由 （DSM 19603）产生的 mcl-PHA 基质中。该生物聚合物具有粘性、生物相容性，且熔融温度为 45°C。我们测试了几种条件，包括压力（15 和 20 MPa）和浸渍时间（30 分钟、1 小时和 3 小时）。在 20 MPa 和 40°C 下，1 小时浸渍时间可获得最高的布洛芬含量（90.8±6.5mg 布洛芬/g），浸渍速率为 89mg/（g·h）。处理后的 mcl-PHA 样品发生了塑性化，表现为 T 下降了 6.5°C，在 20 MPa 下。聚合物的结晶度也与基质中的布洛芬含量同时受到影响。对于所有测试的浸渍条件，布洛芬从生物聚合物中的释放遵循 II 型释放曲线。这项研究表明， 生产的 mcl-PHA 具有开发新型局部药物传递系统的巨大潜力。
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