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不同药物在介孔纳米结构氧化锌中的超临界溶剂浸渍法

Supercritical Solvent Impregnation of Different Drugs in Mesoporous Nanostructured ZnO.

作者信息

Banchero Mauro, Mohamed Sara S Y, Leone Federica, Lopez Francesca, Ronchetti Silvia, Manna Luigi, Onida Barbara

机构信息

Dipartimento di Scienza Applicata e Tecnologia, Politecnico di Torino, Corso Duca degli Abruzzi, 24, 10129 Torino, Italy.

出版信息

Pharmaceutics. 2019 Jul 15;11(7):340. doi: 10.3390/pharmaceutics11070340.

DOI:10.3390/pharmaceutics11070340
PMID:31311208
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6680980/
Abstract

Supercritical solvent impregnation (SSI) is a green unconventional technique for preparing amorphous drug formulations. A mesoporous nanostructured ZnO (mesoNsZnO) carrier with 8-nm pores, spherical-nanoparticle morphology, and an SSA of 75 m/g has been synthesized and, for the first time, subjected to SSI with poorly water-soluble drugs. Ibuprofen (IBU), clotrimazole (CTZ), and hydrocortisone (HC) were selected as highly, moderately, and poorly CO-soluble drugs. Powder X-ray diffraction, Fourier transform infrared spectroscopy, field emission scanning electron microscopy, nitrogen adsorption analysis, and ethanol extraction coupled with ultraviolet spectroscopy were employed to characterize the samples and quantify drug loading. Successful results were obtained with IBU and CTZ while HC loading was negligible, which could be related to different solubilities in CO, drug size, and polarity. Successful SSI resulted in amorphous multilayer confinement of the drug. The mesoNsZnO-IBU system showed double drug loading than the mesoNsZnO-CTZ one, with a maximum uptake of 0.24 g/g. Variation of contact time during SSI of the mesoNsZnO-IBU system showed that drug loading triplicated between 3 and 8 h with an additional 30% increment between 8 h and 24 h. SSI did not affect the mesoNsZnO structure, and the presence of the adsorbed drug reduced the chemisorption of CO on the carrier surface.

摘要

超临界溶剂浸渍（SSI）是一种用于制备无定形药物制剂的绿色非传统技术。已合成了一种具有8纳米孔径、球形纳米颗粒形态且比表面积为75平方米/克的介孔纳米结构氧化锌（mesoNsZnO）载体，并首次将其用于与难溶性药物的SSI过程。选择布洛芬（IBU）、克霉唑（CTZ）和氢化可的松（HC）作为高、中、低CO溶解度的药物。采用粉末X射线衍射、傅里叶变换红外光谱、场发射扫描电子显微镜、氮吸附分析以及乙醇萃取结合紫外光谱对样品进行表征并量化药物负载量。IBU和CTZ取得了成功结果，而HC的负载量可忽略不计，这可能与在CO中的不同溶解度、药物尺寸和极性有关。成功的SSI导致药物形成无定形多层包封。mesoNsZnO - IBU系统的载药量比mesoNsZnO - CTZ系统高两倍，最大摄取量为0.24克/克。mesoNsZnO - IBU系统在SSI过程中接触时间的变化表明，载药量在3至8小时内增加了两倍，在8小时至24小时之间又额外增加了30%。SSI不影响mesoNsZnO的结构，吸附药物的存在降低了CO在载体表面的化学吸附。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2dc/6680980/3968d5554231/pharmaceutics-11-00340-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2dc/6680980/374d0a4a0451/pharmaceutics-11-00340-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2dc/6680980/8828f5de2f8b/pharmaceutics-11-00340-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2dc/6680980/e84030d89ea0/pharmaceutics-11-00340-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2dc/6680980/38d11adb0753/pharmaceutics-11-00340-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2dc/6680980/a7fac5fa80c5/pharmaceutics-11-00340-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2dc/6680980/84efcb7d66ab/pharmaceutics-11-00340-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2dc/6680980/90441cc3e64e/pharmaceutics-11-00340-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2dc/6680980/1dba436feb46/pharmaceutics-11-00340-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2dc/6680980/3968d5554231/pharmaceutics-11-00340-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2dc/6680980/374d0a4a0451/pharmaceutics-11-00340-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2dc/6680980/8828f5de2f8b/pharmaceutics-11-00340-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2dc/6680980/e84030d89ea0/pharmaceutics-11-00340-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2dc/6680980/38d11adb0753/pharmaceutics-11-00340-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2dc/6680980/a7fac5fa80c5/pharmaceutics-11-00340-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2dc/6680980/84efcb7d66ab/pharmaceutics-11-00340-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2dc/6680980/90441cc3e64e/pharmaceutics-11-00340-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2dc/6680980/1dba436feb46/pharmaceutics-11-00340-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2dc/6680980/3968d5554231/pharmaceutics-11-00340-g009.jpg

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