Department of Chemical and Biochemical Engineering, University of Western Ontario, London, ON N6A 5B9, Canada.
Nutrients. 2021 Jul 22;13(8):2492. doi: 10.3390/nu13082492.
Lactoferrin (LF) is one of the major functional proteins in maintaining human health due to its antioxidant, antibacterial, antiviral, and anti-inflammatory activities. Abnormal levels of LF in the human body are related to some serious diseases, such as inflammatory bowel disease, Alzheimer's disease and dry eye disease. Recent studies indicate that LF can be used as a biomarker for diagnosis of these diseases. Many methods have been developed to detect the level of LF. In this review, the biofunctions of LF and its potential to work as a biomarker are introduced. In addition, the current methods of detecting lactoferrin have been presented and discussed. We hope that this review will inspire efforts in the development of new sensing systems for LF detection.
乳铁蛋白（LF）是维持人体健康的主要功能蛋白之一，具有抗氧化、抗菌、抗病毒和抗炎作用。人体内 LF 水平异常与一些严重疾病有关，如炎症性肠病、阿尔茨海默病和干眼症。最近的研究表明，LF 可以作为这些疾病诊断的生物标志物。已经开发了许多方法来检测 LF 的水平。在这篇综述中，介绍了 LF 的生物功能及其作为生物标志物的潜力。此外，还介绍和讨论了目前检测乳铁蛋白的方法。我们希望这篇综述能激发人们开发新的 LF 检测传感系统的努力。
