Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua, via Giustiniani 2, Padua, Italy.
Expert Rev Clin Immunol. 2012 Aug;8(6):579-85. doi: 10.1586/eci.12.50.
The identification of noninvasive biomarkers is still one of the major issue for gastroenterologists dealing with inflammatory bowel disease patients, due to the chronicity of these conditions and the early onset of symptoms in the majority of cases. Research attention has focused mainly on fecal proteins, especially calprotectin and lactoferrin, and most of the published data are reassuring about their applicability in the diagnosis and monitoring of these patients. However, there are still pending questions regarding the reliability of fecal proteins especially in the era of mucosal healing and biologics.
识别非侵入性生物标志物仍然是处理炎症性肠病患者的胃肠病学家面临的主要问题之一，因为这些疾病具有慢性特征，且大多数情况下症状很早就出现了。研究重点主要集中在粪便蛋白上，特别是钙卫蛋白和乳铁蛋白，而且大多数已发表的数据都令人放心，认为它们适用于这些患者的诊断和监测。然而，关于粪便蛋白的可靠性，特别是在黏膜愈合和生物制剂时代，仍然存在悬而未决的问题。
