Pediatrics, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, 71013 Foggia, Italy.
Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy.
Nutrients. 2021 Jul 28;13(8):2586. doi: 10.3390/nu13082586.
The prevalence of primary hypertension in pediatric patients is increasing, especially as a result of the increased prevalence of obesity in children. New diagnostic guidelines for blood pressure were published by the American Academy of Pediatrics (AAP) in 2017 to better define classes of hypertension in children. The aim of our study is to evaluate the impact of new guidelines on diagnosis of hypertension in pediatrics and their capacity to identify the presence of cardiovascular and metabolic risk. Retrospective clinical and laboratory data from 489 overweight and obese children and adolescents were reviewed. Children were classified according to the 2004 and 2017 AAP guidelines for systolic and diastolic blood pressure. Lipid profile and glucose metabolism data were recorded; triglyceride/HDL ratio (TG/HDL) was calculated as an index of endothelial dysfunction. Hepatic steatosis was detected using the ultrasonographic steatosis score. Children with elevated blood pressure increased from 12.5% with the 2004 AAP to 23.1% with the 2017 AAP criteria ( < 0.001). There was a statistically significant increase in children with high blood pressure in all age groups according to the new cut-off values. Notably, the diagnosis of hypertension according to 2017 AAP criteria had a greater positive association with Hepatic Steatosis (rho 0.2, < 0.001) and TG/HDL ratio (rho 0.125, = 0.025). The 2017 AAP tables offer the opportunity to better identify overweight and obese children at risk for organ damage, allowing an earlier and more impactful prevention strategy to be designed.
儿童原发性高血压的患病率正在上升,尤其是由于儿童肥胖症的患病率增加所致。美国儿科学会(AAP)于 2017 年发布了新的血压诊断指南,以更好地定义儿童高血压的类别。我们的研究旨在评估新指南对儿科高血压诊断的影响及其识别心血管和代谢风险的能力。
回顾了 489 名超重和肥胖儿童和青少年的回顾性临床和实验室数据。根据 2004 年和 2017 年 AAP 指南对收缩压和舒张压对儿童进行分类。记录了血脂谱和葡萄糖代谢数据;计算了甘油三酯/高密度脂蛋白比值(TG/HDL)作为内皮功能障碍的指标。使用超声脂肪肝评分检测肝脂肪变性。
根据 2004 年 AAP,患有高血压的儿童从 12.5%增加到 2017 年 AAP 标准的 23.1%(<0.001)。根据新的截止值,所有年龄组中高血压儿童的数量均呈统计学显著增加。值得注意的是,根据 2017 年 AAP 标准诊断的高血压与肝脂肪变性(rho 0.2,<0.001)和 TG/HDL 比值(rho 0.125,= 0.025)呈更强的正相关。
2017 年 AAP 表提供了更好地识别超重和肥胖儿童器官损伤风险的机会,从而可以设计出更早且更具影响力的预防策略。