Hanson C A, Snover D C, Dehner L P
Department of Laboratory Medicine and Pathology, University of Minnesota Medical School and Hospitals, Minneapolis.
Pathology. 1987 Oct;19(4):393-6. doi: 10.3109/00313028709103889.
A benign breast lesion with the composite histologic features of a fibroadenoma and fibrocystic changes has been referred to previously as fibroadenomatosis or fibroadenomatoid mastopathy; this lesion is distinct from the typical well circumscribed fibroadenoma that may have fibrocystic changes. The purpose of our study was to ascertain the frequency of this change among 200 consecutive breast biopsies and excisions with a coded pathologic diagnosis of fibroadenoma and/or "fibrocystic disease"; we identified these changes in 23 (11.5%) specimens. The lesion was characterized by microscopic fibroadenomatoid foci intermingled with dilated ducts, epitheliosis, and adenosis. It is suggested that fibroadenomatosis is yet another pattern in the complex morphologic spectrum known as benign proliferative breast disease. From our experience, this particular lesion was often appreciated as a unique finding, but the appropriate diagnostic designation was in question. The natural history of fibroadenomatosis is essentially unknown. It may represent a morphologic stage in the development of fibroadenoma(s).
一种具有纤维腺瘤和纤维囊性变复合组织学特征的乳腺良性病变，此前被称为纤维腺病或纤维腺样乳腺病；这种病变不同于可能伴有纤维囊性变的典型边界清晰的纤维腺瘤。我们研究的目的是确定在连续200例经编码病理诊断为纤维腺瘤和/或“纤维囊性疾病”的乳腺活检和切除病例中这种改变的发生率；我们在23例（11.5%）标本中发现了这些改变。该病变的特征是显微镜下纤维腺样病灶与扩张的导管、上皮增生和腺病相互交织。有人提出，纤维腺病是被称为良性增生性乳腺疾病的复杂形态学谱中的另一种模式。根据我们的经验，这种特殊病变常被视为独特发现，但合适的诊断名称存在疑问。纤维腺病的自然史基本未知。它可能代表纤维腺瘤发展过程中的一个形态学阶段。
