Datta Abhigyan, Batra Nitya, Pandey Sanjay
Maulana Azad Medical College, and Govind Ballabh Pant Postgraduate Institute of Medical Education and Research, New Delhi, India.
Ann Indian Acad Neurol. 2021 May-Jun;24(3):319-326. doi: 10.4103/aian.AIAN_1264_20. Epub 2021 May 21.
Primary Writing Tremor (PWT) is a type of task specific tremor which happens only while writing (Type A PWT) or assuming a writing position of the hand (Type B PWT). There is a considerable overlap of clinical features between PWT and writer's cramp which creates difficulty in diagnosing this condition in the clinic. PWT usually affects the dominant hand and is typically 5-7hz in frequency, worsened by anxiety, temporarily relieved by alcohol and associated with reduced writing speeds. There are a variety of hypotheses about the phenomenology of PWT (regarding whether it is a variant of essential tremor, focal dystonia or an independent entity). Unlike writer's cramp, PWT shows normal reciprocal inhibition of H reflex, does not exhibit excessive EMG activity in proximal muscles, and on fMRI shows underactivation of cingulum and overactivation of primary motor and supplementary areas. There are no randomised controlled trials currently for the treatment of PWT. Treatment modalities available are: medical treatment, botulinum toxin, surgical management (including DBS) as well as adaptive strategies and occupational therapy.
原发性书写震颤(PWT)是一种特定任务性震颤,仅在书写时(A型PWT)或手部处于书写姿势时(B型PWT)出现。PWT与书写痉挛的临床特征有相当大的重叠,这给临床诊断这种疾病带来了困难。PWT通常影响优势手,频率一般为5 - 7赫兹,焦虑会使其加重,酒精可使其暂时缓解,并伴有书写速度减慢。关于PWT的现象学有多种假说(涉及它是否是特发性震颤、局灶性肌张力障碍的一种变体或一个独立的实体)。与书写痉挛不同,PWT显示H反射的交互抑制正常,近端肌肉不表现出过度的肌电图活动,功能磁共振成像显示扣带回激活不足,初级运动区和辅助运动区激活过度。目前尚无治疗PWT的随机对照试验。可用的治疗方式有:药物治疗、肉毒毒素、手术治疗(包括深部脑刺激术)以及适应性策略和职业治疗。