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任务特异性震颤

Task-specific tremor.

作者信息

Bain Peter G

机构信息

Department of Medicine, Imperial College School of Medicine, Charing Cross Hospital Campus, London, UK.

出版信息

Handb Clin Neurol. 2011;100:711-8. doi: 10.1016/B978-0-444-52014-2.00050-1.

Abstract

Task-specific tremor is a form of action tremor that occurs only or mainly when a person is performing a specific skilled task. The most frequently encountered form of task-specific tremor is primary writing tremor (PWT). Currently, there is debate about whether PWT is a variant of essential tremor, writer's cramp (dystonia), a separate entity, or in some cases related to essential tremor and in others to dystonia. PWT typically occurs at a frequency of 5-7Hz and has been subdivided into to two types: Type A, task-induced tremor, and type B, positionally sensitive tremor. Temporary suppression of the tremor by alcohol is seen in about one-third of cases. There are no randomized controlled therapeutic studies involving patients with PWT, although anecdotal reports of beneficial responses to propranolol, primidone, anticholinergics, botulinum toxin treatment, and stereotactic surgery have been reported. Reciprocal inhibition of the H-reflex and intracortical excitability are normal in PWT, unlike writer's cramp. Hyperactivity in the cerebellar hemispheres has been demonstrated with positron emission tomography in PWT. Other task-specific tremors have been described but have not been studied in detail.

摘要

任务特异性震颤是动作性震颤的一种形式,仅在或主要在个体执行特定的熟练任务时出现。最常见的任务特异性震颤形式是原发性书写震颤(PWT)。目前,关于PWT是特发性震颤的一种变体、书写痉挛(肌张力障碍)、一种独立的疾病实体,还是在某些情况下与特发性震颤相关而在其他情况下与肌张力障碍相关,存在争议。PWT通常以5 - 7Hz的频率出现,并已被细分为两种类型:A型,任务诱发性震颤;B型,位置敏感性震颤。约三分之一的病例中可见震颤被酒精暂时抑制。虽然有关于普萘洛尔、扑米酮、抗胆碱能药物、肉毒毒素治疗及立体定向手术产生有益反应的轶事报道,但尚无涉及PWT患者的随机对照治疗研究。与书写痉挛不同,PWT中H反射的交互抑制和皮质内兴奋性是正常的。正电子发射断层扫描已证实在PWT中小脑半球存在活动亢进。其他任务特异性震颤也有描述,但尚未进行详细研究。

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