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蓝光发光二极管作为盆腔放疗所致阴道狭窄的一种新治疗方法:两例病例报告。

Blue LED as a new treatment to vaginal stenosis due pelvic radiotherapy: Two case reports.

作者信息

Barros Daniela, Alvares Cecília, Alencar Teresa, Baqueiro Priscila, Marianno Augusto, Alves Rafael, Lenzi Juliana, Rezende Laura Ferreira, Lordelo Patricia

机构信息

Oncology Department, Hospital Santa Izabel, Salvador 40290-000, Brazil.

Pelvic Floor Care Center (CAAP) and Postgraduate, Bahiana School of Medicine and Public Health, Salvador 40290-000, Brazil.

出版信息

World J Clin Cases. 2021 Aug 16;9(23):6839-6845. doi: 10.12998/wjcc.v9.i23.6839.

DOI:10.12998/wjcc.v9.i23.6839
PMID:34447833
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8362505/
Abstract

BACKGROUND

Currently, the advancement cancer treatment technology improves overall survival, however, adverse events are still a challenge for health professional. Genitourinary syndrome of menopause and vaginal stenosis are conditions that impact the quality of life of patients undergoing radiotherapy. We present two such cases in patients with previous cervical and endometrial cancer. These conditions were handled with an innovative method using an energy-based device with blue light emitting diode for concomitant vaginal and vulvar irradiation. Positive impact in clinical findings, cytologic changes, and referred symptoms were documented.

CASE SUMMARY

One patient diagnosed with vaginal severe vaginal stenosis with previous cervix cancer treatment and other patient diagnosed with mild stenosis with severe dyspareunia and recent endometrium cancer treatment were considered for vulvovaginal treatment with weekly blue led device and closely evaluated with repeated validated questionnaires and cytological samples.

CONCLUSION

This innovative technique showed an improvement in all areas of the examiner's criteria, the cytological criteria, and most bothered symptoms.

摘要

背景

目前,癌症治疗技术的进步提高了总体生存率,然而,不良事件对医疗专业人员来说仍是一项挑战。更年期泌尿生殖综合征和阴道狭窄会影响接受放疗患者的生活质量。我们介绍两例曾患宫颈癌和子宫内膜癌患者的此类病例。这些情况采用一种创新方法处理,即使用带蓝光发光二极管的能量型设备进行阴道和外阴同步照射。记录了对临床症状、细胞学变化及相关症状的积极影响。

病例总结

一名曾接受宫颈癌治疗、诊断为严重阴道狭窄的患者,以及另一名曾接受子宫内膜癌治疗、诊断为轻度狭窄且伴有严重性交困难的患者,均采用每周一次的蓝光设备进行外阴阴道治疗,并通过反复使用经过验证的问卷和细胞学样本进行密切评估。

结论

这项创新技术在检查标准、细胞学标准以及最困扰症状的所有方面均显示出改善。

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Pract Radiat Oncol. 2019 Nov;9(6):479-491. doi: 10.1016/j.prro.2019.07.001. Epub 2019 Jul 11.
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Blue light-emitting diode in healthy vaginal mucosa-a new therapeutic possibility.健康阴道黏膜中的蓝光发光二极管——一种新的治疗可能性。
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Visual improvements in vaginal mucosa correlate with symptoms of VVA: data from a double-blind, placebo-controlled trial.阴道黏膜的视觉改善与VVA症状相关:一项双盲、安慰剂对照试验的数据
Menopause. 2017 Sep;24(9):1003-1010. doi: 10.1097/GME.0000000000000880.
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Laser therapy as a treatment modality for genitourinary syndrome of menopause: a critical appraisal of evidence.激光疗法作为绝经后泌尿生殖综合征的一种治疗方式:证据的批判性评估
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Inhibitory effect of blue light emitting diode on migration and invasion of cancer cells.蓝光发光二极管对癌细胞迁移和侵袭的抑制作用。
J Cell Physiol. 2017 Dec;232(12):3444-3453. doi: 10.1002/jcp.25805. Epub 2017 Apr 10.
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Proposed Mechanisms of Photobiomodulation or Low-Level Light Therapy.光生物调节或低强度光疗的潜在机制。
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Maintaining sexual health throughout gynecologic cancer survivorship: A comprehensive review and clinical guide.妇科癌症幸存者的性健康维护:全面综述与临床指南
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