边缘旁淋巴结与头颈部癌症的相关性。
Relevance of perimarginal nodes for head and neck cancer.
机构信息
Otorhinolaryngology and Head and Neck Surgery Clinic, Azienda Sanitaria Universitaria Giuliano Isontina-ASUGI, Strada di Fiume 447, 39149, Trieste, Italy.
Istituto di Anatomia Patologica, Università di Trieste, Trieste, Italy.
出版信息
Eur Arch Otorhinolaryngol. 2022 May;279(5):2603-2609. doi: 10.1007/s00405-021-07056-1. Epub 2021 Aug 27.
OBJECTIVE
To estimate the prevalence of metastasis in the perimarginal nodes (PMNs) (also known as perifacial, preglandular and retroglandual nodes) in head and neck cancer.
METHODS
We recruited 136 patients affected by cancers of the oral cavity, lip, oropharynx, skin and by cáncer of unknown primary (CUP), who were candidates for level IB dissection. PMNs were identified and sent separately for histological analysis. Correlation between metastasis to the PMNs and characteristics of the primary tumour were reported.
RESULTS
The incidence of metastasis was 17% from oral cancer, 50% from lip cancer and 12.5% from skin cancer. No metastases were reported for oropharynx cancer or CUP. The only factor that correlated with the incidence of metastases was origin of the tumour from the upper part of oral cavity.
CONCLUSION
PMNs represent a frequent site of metastasis in oral and lip cancers. In cancer of the oropharynx, their involvement has not been not reported, while their role in skin cancers remains to be clarified.
目的
评估头颈部癌症中边缘区淋巴结（PMN）（也称为周围、腺周和腺后淋巴结）转移的发生率。
方法
我们招募了 136 名患有口腔癌、唇癌、口咽癌、皮肤癌和不明原发灶癌（CUP）的患者，他们是进行 I 级 B 区淋巴结清扫术的候选者。识别并单独送检 PMN 进行组织学分析。报告了 PMN 转移与原发肿瘤特征之间的相关性。
结果
口腔癌的转移发生率为 17%，唇癌为 50%，皮肤癌为 12.5%。口咽癌和 CUP 未报告转移。唯一与转移发生率相关的因素是肿瘤起源于口腔上部。
结论
PMN 是口腔和唇癌转移的常见部位。在口咽癌中，尚未报道其受累情况，而其在皮肤癌中的作用仍需阐明。
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