Tirelli Giancarlo, Gatto Annalisa, Marcuzzo Alberto Vito
Department of Otorhinolaryngology and Head and Neck Surgery, Azienda Sanitaria Universitaria Integrata di Trieste-ASUITS, Strada di Fiume 447, 39149, Trieste, Italy.
Eur Arch Otorhinolaryngol. 2019 Apr;276(4):1147-1151. doi: 10.1007/s00405-019-05291-1. Epub 2019 Jan 18.
In a previous study, we gave a surgical description of a group of lymph nodes in the submandibular area at risk of remaining undissected during neck dissection (ND) for which we have proposed the term "perimarginal nodes" (PMNs) due to their proximity to marginal mandibular nerve (MMN). The aim of this study is to evaluate prevalence of PMNs involvement in oral cavity squamous cell cancer (OCSCC) and to verify if metastases are related to primary tumor characteristics or to the state of the neck.
We recruited a total of 39 consecutive patients diagnosed with OCSCC candidate to ND. Histological characteristics of PMNs were analyzed and the incidence of metastases in relation to the primary tumor characteristics were noted.
PMNs were found to be involved with metastases in 8 patients (20.5%). No characteristic of the primary tumor seems to influence the metastatic involvement of the PMNs.
PMNs represent a frequent site of micro-metastases in patients diagnosed with OCSCC regardless of other characteristics of the primary tumor.
在之前的一项研究中，我们对一组在下颌下区域、在颈部清扫术（ND）期间有未被清扫风险的淋巴结进行了手术描述，由于它们靠近下颌缘支神经（MMN），我们将其命名为“边缘周淋巴结”（PMN）。本研究的目的是评估口腔鳞状细胞癌（OCSCC）中PMN受累的患病率，并验证转移是否与原发肿瘤特征或颈部状态相关。
我们共招募了39例连续诊断为OCSCC且拟行ND的患者。分析了PMN的组织学特征，并记录了与原发肿瘤特征相关的转移发生率。
8例患者（20.5%）的PMN发现有转移。原发肿瘤的特征似乎均不影响PMN的转移受累情况。
无论原发肿瘤的其他特征如何，PMN是诊断为OCSCC患者中微转移的常见部位。
