Faculty of Medicine, Kassala University, P.O. Box 1115, Kassala, Sudan.
Department of Pediatrics, Unaizah College of Medicine and Medical Sciences, Qassim University, Unaizah, Kingdom of Saudi Arabia.
Arch Gynecol Obstet. 2022 Apr;305(4):855-858. doi: 10.1007/s00404-021-06204-6. Epub 2021 Aug 27.
Arboviruses (dengue, Zika, and chikungunya) have recently emerged as an important public health issue and can lead to adverse obstetrics outcomes. The current study was conducted to assess maternal and perinatal outcomes following chikungunya fever/infection and to compare adverse pregnancy outcomes with data from the community collected in a previous study.
This study was performed during a chikungunya infection epidemic in Kassala, Sudan by recruiting all pregnant women with a confirmed chikungunya fever diagnosis by using antibodies/detection viral RNA using reverse transcriptase-polymerase chain reaction.
Ninety-three pregnant women with confirmed chikungunya infection were enrolled. Their mean (standard deviation) age and parity were 31.6 (3.4) years and 3.5 (1.4), respectively. Of the 93 women, 58 (62.4%) delivered a live infant at term and 18 (19.4%), 13 (13.9%), and 4 (4.3%) women experienced miscarriage, preterm birth, and stillbirth, respectively. In the logistic regression model, severe thrombocytopenia (platelets < 50,000 cells/mm (odds ratio [OR] = 5.1; confidence interval [CI] 1.8-14; P = 0.001) and leukopenia (OR = 4.5; CI 2.2-8.8; P < 0.001) were predictors for poor obstetric outcomes in pregnant women with chikungunya fever. The rates of miscarriage (18/93 [19.3%] vs. 1/71 [1.4%], P < 0.001) and preterm birth (13/93 [13.9%] vs. 2/71 [2.8%], P = 0.003) were significantly higher in the current study compared with the rate in the community.
Chikungunya infections during pregnancy were associated with miscarriage and preterm birth. Women with severe thrombocytopenia and leukopenia were at higher risk of poor obstetric outcomes. Women with severe thrombocytopenia and leukopenia were at higher risk of poor obstetric outcomes.
虫媒病毒（登革热、 Zika 和基孔肯雅热）最近成为一个重要的公共卫生问题，并可能导致不良的产科结局。本研究旨在评估基孔肯雅热感染/发热后产妇和围产期结局，并将不良妊娠结局与之前社区研究的数据进行比较。
本研究在苏丹卡萨拉发生基孔肯雅热感染流行期间进行，通过使用抗体/检测病毒 RNA 采用逆转录-聚合酶链反应（reverse transcriptase-polymerase chain reaction），招募所有确诊为基孔肯雅热的孕妇。
共纳入 93 例确诊为基孔肯雅热感染的孕妇。她们的平均（标准差）年龄和产次分别为 31.6（3.4）岁和 3.5（1.4）。93 例孕妇中，58 例（62.4%）足月分娩活婴，18 例（19.4%）、13 例（13.9%）和 4 例（4.3%）孕妇分别发生流产、早产和死产。在逻辑回归模型中，严重血小板减少症（血小板 < 50,000 细胞/mm³）（比值比 [OR] = 5.1；置信区间 [CI] 1.8-14；P = 0.001）和白细胞减少症（OR = 4.5；CI 2.2-8.8；P < 0.001）是孕妇患基孔肯雅热后不良产科结局的预测因素。与社区相比，本研究中流产（18/93 [19.3%] vs. 1/71 [1.4%]，P < 0.001）和早产（13/93 [13.9%] vs. 2/71 [2.8%]，P = 0.003）的发生率明显更高。
孕妇感染基孔肯雅热与流产和早产有关。严重血小板减少症和白细胞减少症的妇女发生不良产科结局的风险更高。
