妊娠期和围生期感染寨卡病毒的新生儿结局：库拉索岛寨卡病毒爆发期间的观察性研究
Perinatal Outcomes in Vertically Infected Neonates During a Chikungunya Outbreak on the Island of Curaçao.
机构信息
Department of Obstetrics and Gynecology, Saint Elisabeth Hospital, Willemstad, Curaçao.
Global Child Health Group, Emma Children's Hospital, Amsterdam Medical Centre (AMC), Amsterdam, The Netherlands.
出版信息
Am J Trop Med Hyg. 2018 Dec;99(6):1415-1418. doi: 10.4269/ajtmh.17-0957.
Abstract
Recent outbreaks of Chikungunya virus (CHIKV) infection confirm the vulnerability of neonates after vertical transmission. In 2014, CHIKV was reported for the first time in the Americas, including the island of Curaçao. We describe the outcomes of symptomatic neonates with vertically transmitted CHIKV infection during the CHIKV epidemic, who were admitted in the Saint Elisabeth Hospital, Willemstad, Curaçao. There were three symptomatic neonates with serologically confirmed infection. Two neonates developed neurological complications, including convulsions and intracerebral bleeding. One newborn, in whom maternal infection occurred 7 weeks before delivery, had a fatal outcome after birth. Maternal-fetal transmission of CHIKV may cause severe neonatal complications. There is a need to share experiences and to implement protocols toward the management of perinatal CHIKV infection.
摘要
近年来基孔肯雅热病毒（CHIKV）感染的爆发证实了新生儿在垂直传播后的易感性。2014 年，CHIKV 首次在美洲报告，包括库拉索岛。我们描述了在库拉索圣伊丽莎白医院住院的垂直传播 CHIKV 感染的有症状新生儿的结局。有 3 例有症状的新生儿经血清学确认感染。2 例新生儿出现神经系统并发症，包括抽搐和颅内出血。1 例新生儿在分娩前 7 周时母体感染，出生后死亡。CHIKV 的母婴传播可能导致严重的新生儿并发症。有必要分享经验并制定围产期 CHIKV 感染的管理方案。
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