Azum Naved, Rub Malik Abdul, Asiri Abdullah M
Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Polymers (Basel). 2021 Aug 17;13(16):2756. doi: 10.3390/polym13162756.
In drug delivery, surfactants are used to reduce side effects and to increase drug efficiency. The present work aimed to study the interaction of diphenhydramine hydrochloride (anti-allergic drug) with TX-45 (non-ionic surfactant) in the absence and presence of ionic liquid (1-hexyl-3-methylimidazolium chloride). The physicochemical parameters were estimated by the surface tension measurement. Various theoretical models (Clint, Rubingh, Motomura, and Maeda) were applied to determine the attractive behavior between drug and surfactant mixtures at the surface and in bulk. The drug and surfactant mixtures exhibit synergistic behavior in the absence and presence of ionic liquid. Several energetic parameters were also estimated with the assistance of regular solution approximation and pseudo phase separation model that indicate micelle formation and adsorption of surfactant at the surface is thermodynamically advantageous. The morphology of pure and mixture of amphiphiles has been estimated by the Tanford and Israelachvili theories. UV-visible spectroscopy was used to quantify the attractive behavior of the drug with surfactant with the help of a binding constant ().
在药物递送中，表面活性剂用于减少副作用并提高药物效率。本工作旨在研究盐酸苯海拉明（抗过敏药物）与TX - 45（非离子表面活性剂）在不存在和存在离子液体（1 - 己基 - 3 - 甲基咪唑鎓氯化物）的情况下的相互作用。通过表面张力测量估算物理化学参数。应用各种理论模型（克林特、鲁宾、本村和前田）来确定药物与表面活性剂混合物在表面和本体中的吸引行为。药物与表面活性剂混合物在不存在和存在离子液体的情况下均表现出协同行为。还借助正规溶液近似和假相分离模型估算了几个能量参数，这些参数表明表面活性剂在表面形成胶束和吸附在热力学上是有利的。两亲物的纯品和混合物的形态已通过坦福德和以色列阿茨维利理论进行了估算。紫外可见光谱法借助结合常数（）用于量化药物与表面活性剂的吸引行为。
