Azum Naved, Rub Malik Abdul, Khan Anish, Alotaibi Maha M, Asiri Abdullah M
Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Gels. 2022 Apr 11;8(4):234. doi: 10.3390/gels8040234.
Surfactants are ubiquitous materials that are used in diverse formulations of various products. For instance, they improve the formulation of gel by improving its wetting and rheological properties. Here, we describe the effects of anionic surfactants on an anesthetic drug, tetracaine hydrochloride (TCH), in NaCl solution with tensiometry and UV-visible techniques. Various micellar, interfacial, and thermodynamic parameters were estimated. The outputs were examined by using different theoretical models to attain a profound knowledge of drug-surfactant mixtures. The presence of attractive interactions among drug and surfactant monomers (synergism) in mixed micelle was inferred. However, it was found that sodium dodecyl sulfate (SDS) showed greater interactions with the drug in comparison to sodium lauryl sarcosine (SLS). The binding of the drug with surfactants was monitored with a spectroscopic technique (UV-visible spectra). The results of this study could help optimize the compositions of these mixed aggregates and find the synergism between monomers of different used amphiphiles.
表面活性剂是广泛存在的物质，用于各种产品的不同配方中。例如，它们通过改善凝胶的润湿性和流变特性来改进凝胶配方。在此，我们用表面张力测定法和紫外可见技术描述了阴离子表面活性剂对麻醉药物盐酸丁卡因（TCH）在氯化钠溶液中的影响。估算了各种胶束、界面和热力学参数。通过使用不同的理论模型对结果进行检验，以深入了解药物 - 表面活性剂混合物。推断出混合胶束中药物和表面活性剂单体之间存在吸引相互作用（协同作用）。然而，发现十二烷基硫酸钠（SDS）与药物的相互作用比月桂酰肌氨酸钠（SLS）更强。用光谱技术（紫外可见光谱）监测药物与表面活性剂的结合。本研究结果有助于优化这些混合聚集体的组成，并找到不同所用两亲物单体之间的协同作用。
