Abd Rahman Aina Nadheera, Hasnul Hadi Nurul Husna, Sun Zhong, Thilakavathy Karuppiah, Joseph Narcisse
Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia.
Genetics and Regenerative Medicine Research Group, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia.
Pathogens. 2021 Jul 27;10(8):943. doi: 10.3390/pathogens10080943.
Leptospirosis is one of the most widespread bacterial diseases caused by pathogenic . There are broad clinical manifestations due to varied pathogenicity of spp., which can be classified into three clusters such as pathogenic, intermediate, and saprophytic. Intermediate spp. can either be pathogenic or non-pathogenic and they have been reported to cause mild to severe forms of leptospirosis in several studies, contributing to the disease burden. Hence, this study aimed to estimate the global prevalence of intermediate spp. in humans using meta-analysis with region-wise stratification. The articles were searched from three databases which include PubMed, Scopus, and ScienceDirect. Seven studies were included consisting of two regions based on United Nations geo-scheme regions, among 469 records identified. Statistical analysis was performed using RevMan software. The overall prevalence estimate of intermediate spp. in humans was 86% and the pooled prevalences were 96% and 17% for the American and Asia regions, respectively. The data also revealed that was the most predominantly found compared to the other intermediate species identified from the included studies, which were and . The estimated prevalence data from this study could be used to develop better control and intervention strategies in combating human leptospirosis.
钩端螺旋体病是由致病性[病原体名称未给出]引起的最广泛传播的细菌性疾病之一。由于[病原体名称未给出]菌株的致病性各不相同，临床表现广泛，可分为致病性、中间型和腐生型三类。中间型[病原体名称未给出]菌株既可能致病也可能不致病，在多项研究中据报道它们可导致从轻度到重度的钩端螺旋体病，加重了疾病负担。因此，本研究旨在通过按区域分层的荟萃分析来估计人类中间型[病原体名称未给出]菌株的全球流行率。从包括PubMed、Scopus和ScienceDirect在内的三个数据库中检索文章。在鉴定出的469条记录中，纳入了七项研究，这些研究基于联合国地理区域划分包括两个区域。使用RevMan软件进行统计分析。人类中间型[病原体名称未给出]菌株的总体流行率估计为86%，美洲和亚洲区域的合并流行率分别为96%和17%。数据还显示，与纳入研究中鉴定出的其他中间型菌株[其他菌株名称未给出]相比，[主要菌株名称未给出]是最主要发现的菌株。本研究的估计流行率数据可用于制定更好的控制和干预策略以对抗人类钩端螺旋体病。
