Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup-si, Jeollabuk-do 56212, Korea.
College of Pharmacy, Chonnam National University, Gwangju 61186, Korea.
Molecules. 2020 Sep 23;25(19):4370. doi: 10.3390/molecules25194370.
A new polyacetylene glycoside, (5)-6-tetradecene-8,10,12-triyne-1-ol-5---glucoside (), was isolated from the flower of (Compositae), together with two known compounds, bidenoside C () and (3,4)-5-trideca-1,5-dien-7,9,11-triyne-3,4-diol-4---glucopyranoside (), which were found in species for the first time. The other known compounds, lanceoletin (), 3,2'-dihydroxy-4-3'-dimethoxychalcone-4'-glucoside (), 4-methoxylanceoletin (), lanceolin (), leptosidin (), (2)-8-methoxybutin (), luteolin () and quercetin (), were isolated in this study and reported previously from this plant. The structure of was elucidated by analyzing one-dimensional and two-dimensional nuclear magnetic resonance and high resolution-electrospray ionization-mass spectrometry data. All compounds were tested for their dipeptidyl peptidase IV (DPP-IV) inhibitory activity and compounds -, and inhibited DPP-IV activity in a concentration-dependent manner, with IC values from 9.6 to 64.9 μM. These results suggest that flower and its active constituents show potential as therapeutic agents for diseases associated with type 2 diabetes mellitus.
一种新的聚乙炔糖苷，（5）-6-十四碳二烯-8,10,12-三炔-1-醇-5---葡萄糖苷（），从（菊科）的花中分离出来，同时分离出两种已知化合物，双糖苷 C（）和（3,4）-5-十三碳-1,5-二烯-7,9,11-三炔-3,4-二醇-4---葡萄糖苷（），这两种化合物首次在 中发现。其他已知化合物，藜芦酮（），3,2'-二羟基-4-3'-二甲氧基查耳酮-4'-葡萄糖苷（），4-甲氧基藜芦酮（），藜芦醇（），leptosidin（），（2）-8-甲氧基丁烯（），木犀草素（）和槲皮素（），在本研究中分离出来，并以前从该植物中报道过。通过分析一维和二维核磁共振和高分辨率电喷雾电离质谱数据，确定了 的结构。所有化合物均进行了二肽基肽酶 IV（DPP-IV）抑制活性测试，化合物 - ， 和 以浓度依赖的方式抑制 DPP-IV 活性，IC 值为 9.6 至 64.9 μM。这些结果表明，花及其活性成分具有作为治疗与 2 型糖尿病相关疾病的潜在治疗剂的潜力。
