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意大利伦巴第地区流行的一种对中和抗体敏感性降低的谱系 C.36 SARS-CoV-2 分离株的特征。

Characterization of a Lineage C.36 SARS-CoV-2 Isolate with Reduced Susceptibility to Neutralization Circulating in Lombardy, Italy.

机构信息

Laboratory of Microbiology and Virology, Vita-Salute San Raffaele University, 20132 Milan, Italy.

Laboratory of Microbiology, ASST Sette Laghi, 21100 Varese, Italy.

出版信息

Viruses. 2021 Jul 31;13(8):1514. doi: 10.3390/v13081514.

DOI:10.3390/v13081514
PMID:34452380
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8402759/
Abstract

SARS-CoV-2 spike is evolving to maximize transmissibility and evade the humoral response. The massive genomic sequencing of SARS-CoV-2 isolates has led to the identification of single-point mutations and deletions, often having the recurrence of hotspots, associated with advantageous phenotypes. We report the isolation and molecular characterization of a SARS-CoV-2 strain, belonging to a lineage (C.36) not previously associated with concerning traits, which shows decreased susceptibility to vaccine sera neutralization.

摘要

SARS-CoV-2 的刺突蛋白不断进化，以最大限度地提高传染性并逃避体液免疫反应。对 SARS-CoV-2 分离株的大规模基因组测序导致了单点突变和缺失的鉴定，这些突变和缺失通常会反复出现热点，与有利的表型相关。我们报告了一种 SARS-CoV-2 株的分离和分子特征，该株属于以前与令人关注的特征无关的谱系（C.36），其对疫苗血清中和的敏感性降低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bd1/8402759/743e93c3d2bb/viruses-13-01514-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bd1/8402759/eec9130be330/viruses-13-01514-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bd1/8402759/7341a44f0d26/viruses-13-01514-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bd1/8402759/743e93c3d2bb/viruses-13-01514-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bd1/8402759/eec9130be330/viruses-13-01514-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bd1/8402759/7341a44f0d26/viruses-13-01514-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bd1/8402759/743e93c3d2bb/viruses-13-01514-g003.jpg

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