Parish E J, Nanduri V B, Seikel J M, Kohl H H, Nusbaum K E
Department of Chemistry, Auburn University, Alabama 36849-3501.
Steroids. 1986 Nov-Dec;48(5-6):407-18. doi: 10.1016/0039-128x(86)90027-9.
An efficient procedure for the chemical synthesis of 3 beta-hydroxy-5 alpha-cholest-8-en-7-one and 3 beta-hydroxy-5 alpha-cholest-8-en-11-one is described. These ketosterols have been shown to have possible significant hypocholesterolemic effects when fed to normal rats at a level of 0.15% in a laboratory chow diet. The diets containing the steroids caused significant decreases in food consumption which were associated with decreases in the rate of gain in body weight.
