Inhibitors of sterol synthesis. Hypocholesterolemic action of dietary 9 alpha-fluoro-5 alpha-cholest-8(14)-en-3 beta-ol-15-one.
作者信息
Schroepfer G J, Walker V, Parish E J, Kisic A
出版信息
Biochem Biophys Res Commun. 1980 Apr 14;93(3):813-8. doi: 10.1016/0006-291x(80)91149-3.
PMID:7387678
Abstract
摘要
相似文献
1
Inhibitors of sterol synthesis. Hypocholesterolemic action of dietary 9 alpha-fluoro-5 alpha-cholest-8(14)-en-3 beta-ol-15-one.固醇合成抑制剂。膳食中9α-氟-5α-胆甾-8(14)-烯-3β-醇-15-酮的降胆固醇作用。
Biochem Biophys Res Commun. 1980 Apr 14;93(3):813-8. doi: 10.1016/0006-291x(80)91149-3.
2
Inhibition of sterol biosynthesis by 9 alpha-fluoro and 9 alpha-hydroxy derivatives of 5 alpha-cholest-8(14)-en-3 beta-ol-15-one.5α-胆甾-8(14)-烯-3β-醇-15-酮的9α-氟和9α-羟基衍生物对甾醇生物合成的抑制作用
Biochem Biophys Res Commun. 1979 Nov 28;91(2):606-13. doi: 10.1016/0006-291x(79)91565-1.
3
Inhibitors of sterol synthesis. Hypocholesterolemic action of dietary 5alpha-cholest-8(14)-en-3beta-ol-15-one in rats and mice.固醇合成抑制剂。膳食中5α-胆甾-8(14)-烯-3β-醇-15-酮对大鼠和小鼠的降胆固醇作用。
Biochem Biophys Res Commun. 1977 Oct 24;78(4):1227-33. doi: 10.1016/0006-291x(77)91424-3.
4
Inhibitors of sterol synthesis. Dietary administration of 5 alpha-cholest-8(14)-en-3 beta-ol-15-one inhibits the intestinal absorption of cholesterol in lymph-cannulated rats.固醇合成抑制剂。给经淋巴管插管的大鼠经饮食给予5α-胆甾-8(14)-烯-3β-醇-15-酮可抑制胆固醇的肠道吸收。
Biochem Biophys Res Commun. 1987 Aug 14;146(3):1003-8. doi: 10.1016/0006-291x(87)90747-9.
5
Inhibitors of sterol synthesis. The effects of dietary 5 alpha-cholest-8(14)-en-3 beta-ol-15-one on the fate of [4-14C]cholesterol and [2,4-3H]5 alpha-cholest-8(14)-en-3 beta-ol-15-one after intragastric administration to rats.固醇合成抑制剂。大鼠经胃内给予膳食5α-胆甾-8(14)-烯-3β-醇-15-酮后，其对[4-¹⁴C]胆固醇和[2,4-³H]5α-胆甾-8(14)-烯-3β-醇-15-酮代谢命运的影响。
Chem Phys Lipids. 1988 May;47(1):1-20. doi: 10.1016/0009-3084(88)90029-1.
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Inhibitors of sterol synthesis. Effect of dietary 5 alpha-cholest-8(14)-en-3 beta-ol-15-one on ACAT activity of jejunal microsomes of the rat.
Biochem Biophys Res Commun. 1987 Nov 13;148(3):920-5. doi: 10.1016/s0006-291x(87)80220-6.
7
Inhibition of hepatic sterol synthesis and reduction of serum cholesterol in rats by 5alpha-cholest-8(14)-en-3beta-ol-15-one.5α-胆甾-8(14)-烯-3β-醇-15-酮对大鼠肝脏甾醇合成的抑制作用及血清胆固醇的降低
Biochem Biophys Res Commun. 1976 Aug 23;71(4):98409. doi: 10.1016/0006-291x(76)90751-8.
8
5 alpha-Cholest-8(14)-en-3 beta-ol-15-one, a potent inhibitor of sterol biosynthesis, lowers serum cholesterol and alters distributions of cholesterol in lipoproteins in baboons.5α-胆甾-8(14)-烯-3β-醇-15-酮，一种有效的甾醇生物合成抑制剂，可降低狒狒的血清胆固醇并改变脂蛋白中胆固醇的分布。
Proc Natl Acad Sci U S A. 1982 May;79(9):3042-6. doi: 10.1073/pnas.79.9.3042.
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Inhibition of sterol biosynthesis by 14 alpha-hydroxy-delta 7-sterols.14α-羟基-Δ7-甾醇对甾醇生物合成的抑制作用。
Experientia. 1980 May 15;36(5):518. doi: 10.1007/BF01965773.
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Inhibition of sterol synthesis in L cells by 14alpha-ethyl-5alpha-cholest-7-en-15alpha-ol-3-one at nanomolar concentrations.14α-乙基-5α-胆甾-7-烯-15α-醇-3-酮在纳摩尔浓度下对L细胞中甾醇合成的抑制作用。
Biochem Biophys Res Commun. 1977 Nov 21;79(2):406-10. doi: 10.1016/0006-291x(77)90172-3.
引用本文的文献
1
5 alpha-Cholest-8(14)-en-3 beta-ol-15-one, a potent inhibitor of sterol biosynthesis, lowers serum cholesterol and alters distributions of cholesterol in lipoproteins in baboons.5α-胆甾-8(14)-烯-3β-醇-15-酮，一种有效的甾醇生物合成抑制剂，可降低狒狒的血清胆固醇并改变脂蛋白中胆固醇的分布。
Proc Natl Acad Sci U S A. 1982 May;79(9):3042-6. doi: 10.1073/pnas.79.9.3042.
2
Oxysterols: chemical synthesis, biosynthesis and biological activities.氧化甾醇：化学合成、生物合成及生物活性
Lipids. 1986 Jan;21(1):27-30. doi: 10.1007/BF02534299.
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