固醇合成抑制剂。给经淋巴管插管的大鼠经饮食给予5α-胆甾-8(14)-烯-3β-醇-15-酮可抑制胆固醇的肠道吸收。
Inhibitors of sterol synthesis. Dietary administration of 5 alpha-cholest-8(14)-en-3 beta-ol-15-one inhibits the intestinal absorption of cholesterol in lymph-cannulated rats.
作者信息
Schroepfer G J, Christophe A, Needleman D H, Kisic A, Sherrill B C
出版信息
Biochem Biophys Res Commun. 1987 Aug 14;146(3):1003-8. doi: 10.1016/0006-291x(87)90747-9.
PMID:3619910
Abstract
The effect of 5 alpha-cholest-8(14)-en-3 beta-ol-15-one, a potent inhibitor of cholesterol synthesis with marked hypocholesterolemic activity, on the intestinal absorption of exogenous cholesterol has been studied in lymph-cannulated rats. Administration of the 15-ketosterol at a level of 0.05% in a rat chow diet for 10 days was associated with a marked decrease (-64%) in the absorption of cholesterol.
摘要
5α-胆甾-8(14)-烯-3β-醇-15-酮是一种具有显著降胆固醇活性的强效胆固醇合成抑制剂，本研究在淋巴插管大鼠中探讨了其对外源性胆固醇肠道吸收的影响。在大鼠饲料中添加0.05%的15-酮甾醇并持续喂养10天，结果显示胆固醇吸收显著下降（-64%）。
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