一种儿茶酚型9,10-开环甾体，为假单胞菌属对胆酸进行需氧分解代谢的产物。

A catecholic 9,10-seco steroid as a product of aerobic catabolism of cholic acid by a Pseudomonas sp.

作者信息

Park R J, Dunn N W, Ide J A

机构信息

CSIRO Division of Food Research, Meat Research Laboratory, Queensland, Australia.

出版信息

Steroids. 1986 Nov-Dec;48(5-6):439-50. doi: 10.1016/0039-128x(86)90030-9.

DOI:10.1016/0039-128x(86)90030-9

PMID:3445293

Abstract

A mutant of the efficient bile acid-utilizing Pseudomonas putida ATCC 31752 was found to accumulate three major catabolites on aerobic growth on cholic acid. One of these catabolites was isolated and identified as 3,4,7,12 beta-tetrahydroxy-9,10-seco-1,3,5(10)-androstatriene-9,17-dione (2). This is the first catecholic 9,10-secosteroid isolated from the microbial degradation of bile acids or sterols and confirms the role of such secosteroids in the microbial degradative pathway for steroids.

摘要

人们发现，高效利用胆汁酸的恶臭假单胞菌ATCC 31752的一个突变体在以胆酸为有氧生长底物时会积累三种主要的分解代谢产物。其中一种分解代谢产物被分离出来并鉴定为3,4,7,12β-四羟基-9,10-开环-1,3,5(10)-雄甾三烯-9,17-二酮（2）。这是首次从胆汁酸或甾醇的微生物降解中分离出的儿茶酚型9,10-开环甾类化合物，证实了此类开环甾类化合物在甾类微生物降解途径中的作用。